TYMP (gene)

TYMP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UOU, 2J0F, 2WK5, 2WK6
Identifiers
Aliases	TYMP, thymidine phosphorylase, ECGF, ECGF1, MEDPS1, MNGIE, MTDPS1, PDECGF, TP, hPD-ECGF
External IDs	OMIM: 131222 MGI: 1920212 HomoloGene: 1474 GeneCards: TYMP
Gene location (Human)
Chr.	Chromosome 22 (human)
End	50,530,032 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	89,261,242 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; monocyte; ; right lung; ; upper lobe of left lung; ; spleen; ; blood; ; right lobe of liver; ; gallbladder; ; minor salivary glands; ; right coronary artery;
	Top expressed in
	liver; ; jejunum; ; colon; ; duodenum; ; spermatocyte; ; vagina; ; spermatid; ; testicle; ; proximal tubule; ; lung;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; glycosyltransferase activity; pyrimidine-nucleoside phosphorylase activity; growth factor activity; pentosyltransferase activity; 1,4-alpha-oligoglucan phosphorylase activity; thymidine phosphorylase activity; protein homodimerization activity;
Cellular component	cytosol;
Biological process	cell differentiation; pyrimidine nucleoside salvage; pyrimidine nucleoside catabolic process; multicellular organism development; chemotaxis; angiogenesis; metabolism; pyrimidine nucleobase metabolic process; mitochondrial genome maintenance; pyrimidine nucleoside metabolic process; regulation of myelination; regulation of transmission of nerve impulse; regulation of gastric motility; regulation of signaling receptor activity; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	1890
	72962
	ENSG00000025708
	ENSMUSG00000022615
	P19971
	Q99N42
	NM_001953; NM_001113755; NM_001113756; NM_001257988; NM_001257989
	NM_138302; NM_028405
	NP_001107227; NP_001107228; NP_001244917; NP_001244918; NP_001944
	NP_612175
	Wikidata
View/Edit Human	View/Edit Mouse

Thymidine phosphorylase is an enzyme that in humans is encoded by the TYMP gene.^[5]^[6]

Template:PBB Summary

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000025708 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022615 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Usuki K, Saras J, Waltenberger J, Miyazono K, Pierce G, Thomason A, Heldin CH (Jun 1992). "Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity". Biochem Biophys Res Commun. 184 (3): 1311–6. doi:10.1016/S0006-291X(05)80025-7. PMID 1590793.
^ Spinazzola A, Marti R, Nishino I, Andreu AL, Naini A, Tadesse S, Pela I, Zammarchi E, Donati MA, Oliver JA, Hirano M (Feb 2002). "Altered thymidine metabolism due to defects of thymidine phosphorylase". J Biol Chem. 277 (6): 4128–33. doi:10.1074/jbc.M111028200. PMID 11733540.{{cite journal}}: CS1 maint: unflagged free DOI (link)

External links

GeneReviews/NIH/NCBI/UW entry on Mitochondrial Neurogastrointestinal Encephalopathy Disease (MNGIE)

Interactive pathway map

References

External links

Further reading