Fyn-related kinase

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FRK
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FRK, GTK, PTK5, RAK, Fyn-related kinase, fyn related Src family tyrosine kinase
External IDs MGI: 103265 HomoloGene: 48065 GeneCards: FRK
Targeted by Drug
bosutinib[1]
RNA expression pattern
PBB GE FRK 207178 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002031

NM_001159544
NM_010237

RefSeq (protein)

NP_002022

NP_001153016.1
NP_034367.2
NP_001153016
NP_034367

Location (UCSC) Chr 6: 115.93 – 116.06 Mb Chr 10: 34.48 – 34.61 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.[4][5]

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.[5]

Interactions[edit]

FRK has been shown to interact with retinoblastoma protein.[6]

References[edit]

  1. ^ "Drugs that physically interact with Fyn related Src family tyrosine kinase view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT (April 1994). "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene". Gene. 138 (1-2): 247–51. doi:10.1016/0378-1119(94)90817-6. PMID 7510261. 
  5. ^ a b "Entrez Gene: FRK fyn-related kinase". 
  6. ^ Craven, R J; Cance W G; Liu E T (September 1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. UNITED STATES. 55 (18): 3969–72. ISSN 0008-5472. PMID 7664264. 

Further reading[edit]