Fc receptor-like molecule

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Fc receptor-like molecules (FCRLs) are a class of proteins that resemble Fc receptors. They have been characterized in a number of species, including humans and mice. They are preferentially expressed by B lymphocytes. Unlike the classical Fc receptors, there is no strong evidence that suggests that FCRLs bind to the Fc portion of antibodies. Their function is unknown.[1]

It has been indicated that FCRLs may be a unique marker for immune cells in the brain called microglia, compared to other CNS cells and peripheral immune cells.[2]


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  1. ^ Davis RS (2007). "Fc receptor-like molecules". Annual Review of Immunology. 25: 525–60. PMID 17201682. doi:10.1146/annurev.immunol.25.022106.141541. 
  2. ^ Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, Gygi SP, Antel JP, Weiner HL (January 2014). "Identification of a unique TGF-β-dependent molecular and functional signature in microglia". Nature Neuroscience. 17 (1): 131–43. PMC 4066672Freely accessible. PMID 24316888. doi:10.1038/nn.3599. 
  3. ^ Santiago T, Kulemzin SV, Reshetnikova ES, Chikaev NA, Volkova OY, Mechetina LV, Zhao M, Davis RS, Taranin AV, Najakshin AM, Hendershot LM, Burrows PD (January 2011). "FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgA". International Immunology. 23 (1): 43–53. PMC 3003704Freely accessible. PMID 21149418. doi:10.1093/intimm/dxq456. 

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