Inositol-polyphosphate multikinase
| Inositol-polyphosphate multikinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.151 | ||||||||
| CAS no. | 9077-69-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Inositol-polyphosphate multikinase (EC 2.7.1.151, IpK2, IP3/IP4 6-/3-kinase, IP3/IP4 dual-specificity 6-/3-kinase, IpmK, ArgRIII, AtIpk2alpha, AtIpk2beta, inositol polyphosphate 6-/3-/5-kinase) is an enzyme with systematic name ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (overall reaction)
- (1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
- (1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown.
References
- ^ Saiardi, A., Erdjument-Bromage, H., Snowman, A.M., Tempst, P. and Snyder, S.H. (1999). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Curr. Biol. 9: 1323–1326. doi:10.1016/S0960-9822(00)80055-X. PMID 10574768.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Odom, A.R., Stahlberg, A., Wente, S.R. and York, J.D. (2000). "A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control". Science. 287 (5460): 2026–2029. doi:10.1126/science.287.5460.2026. PMID 10720331.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Stevenson-Paulik, J., Odom, A.R. and York, J.D. (2002). "Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases". J. Biol. Chem. 277: 42711–42718. doi:10.1074/jbc.M209112200. PMID 12226109.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Verbsky, J.W., Chang, S.C., Wilson, M.P., Mochizuki, Y. and Majerus, P.W. (2005). "The pathway for the production of inositol hexakisphosphate in human cells". J. Biol. Chem. 280 (3): 1911–1920. doi:10.1074/jbc.M411528200. PMID 15531582.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)