Limulus clotting factor C

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Limulus clotting factor overbar C
EC number3.4.21.84
CAS number115743-27-6
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

Limulus clotting factor overbar C (EC, factor C, limulus factor C) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Selective cleavage of -Arg103-Ser- and -Ile124-Ile- bonds in limulus clotting factor B to form factor overbar B. Cleavage of -Pro-Arg- bonds in synthetic substrates

This enzyme is isolated from the hemocyte granules of the horseshoe crabs Limulus and Tachypleus.


  1. ^ Nakamura T, Morita T, Iwanaga S (February 1986). "Lipopolysaccharide-sensitive serine-protease zymogen (factor C) found in Limulus hemocytes. Isolation and characterization". European Journal of Biochemistry. 154 (3): 511–21. doi:10.1111/j.1432-1033.1986.tb09427.x. PMID 3512266.
  2. ^ Muta T, Miyata T, Misumi Y, Tokunaga F, Nakamura T, Toh Y, Ikehara Y, Iwanaga S (April 1991). "Limulus factor C. An endotoxin-sensitive serine protease zymogen with a mosaic structure of complement-like, epidermal growth factor-like, and lectin-like domains". The Journal of Biological Chemistry. 266 (10): 6554–61. PMID 2007602.
  3. ^ Tokunaga F, Nakajima H, Iwanaga S (January 1991). "Further studies on lipopolysaccharide-sensitive serine protease zymogen (factor C): its isolation from Limulus polyphemus hemocytes and identification as an intracellular zymogen activated by alpha-chymotrypsin, not by trypsin". Journal of Biochemistry. 109 (1): 150–7. PMID 2016264.

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