Nooglutyl

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Erik.Bjareholt (talk | contribs) at 06:53, 18 October 2018 ("is studied" -> "was studied"). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Nooglutyl
Names
IUPAC name
N-[(5-Hydroxy-3-pyridinyl)carbonyl]-L-glutamic acid
Other names
Nooglutil
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C11H12N2O6/c14-7-3-6(4-12-5-7)10(17)13-8(11(18)19)1-2-9(15)16/h3-5,8,14H,1-2H2,(H,13,17)(H,15,16)(H,18,19)/t8-/m0/s1
    Key: XFZGYOJFPGPYCS-QMMMGPOBSA-N
  • InChI=1/C11H12N2O6/c14-7-3-6(4-12-5-7)10(17)13-8(11(18)19)1-2-9(15)16/h3-5,8,14H,1-2H2,(H,13,17)(H,15,16)(H,18,19)/t8-/m0/s1
    Key: XFZGYOJFPGPYCS-QMMMGPOBBD
  • O=C(c1cncc(O)c1)N[C@H](C(=O)O)CCC(=O)O
Properties
C11H12N2O6
Molar mass 268.225 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Nooglutyl is a nootropic agent that was studied at the Research Institute of Pharmacology, Russian Academy of Medical Sciences as a potential treatment for amnesia.[1]

In animal models, it has a variety of central nervous system effects.[2][3][4][5]

References

  1. ^ Flekhter, Oxana B. (2000). "Nooglutil, Russian Academy of Medical Science". Current Opinion in Central & Peripheral Nervous System Investigational Drugs. 2 (4): 491–497.
  2. ^ V. V. Yasnetsov; V. A. Pravdivtsev; V. M. Popov; T. A. Voronina; N. M. Kiseleva; S. B. Kozlov (May 1995). "Antimotion Effect of Nooglutyl and Its Neuronal Mechanism". Bulletin of Experimental Biology and Medicine. 119 (5): 515–516. doi:10.1007/BF02543440. PMID 7579248. Retrieved 2011-02-08.
  3. ^ Voronina, TA; Borlikova, GG; Garibova, TL; Proskuryakova, TV; Petrichenko, OB; Burd, SG; Avakyan, GN (2002). "Effect of nooglutil on benzodiazepine withdrawal syndrome and binding of 3H-spiperone with D2 receptors in rat striatum". Bulletin of experimental biology and medicine. 134 (5): 448–50. PMID 12802448.
  4. ^ Garibova, TL; Galaeva, IP; Voronina, TA; Kraĭneva, VA; Kapitsa, IG; Kirichenko, SV; Makarenko, AN; Mirzoian, GR; Kuznetsova, EA (2003). "Effect of nooglutil on rats with intracerebral posttraumatic hematoma (hemorrhagic stroke)". Eksperimental'naia i klinicheskaia farmakologiia. 66 (3): 13–6. PMID 12924225.
  5. ^ Povarova, OV; Garibova, TL; Kalenikova, EI; Galaeva, IP; Kraĭneva, VA; Medvedev, OS; Voronina, TA (2004). "Effect of phenyl-tert-butylnitrone, mexidol and nooglutil on the ischemic lesion zone and memory in rats following middle cerebral artery occlusion". Eksperimental'naia i klinicheskaia farmakologiia. 67 (1): 3–6. PMID 15079898.


Template:Nootropics


Stub icon

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Nooglutyl&oldid=864593038"