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Systematic (IUPAC) name
Clinical data
Legal status
Routes of
Metabolite of Iboga-alkaloid(s?) Ibogaine.
CAS Registry Number 481-88-9 N
PubChem CID: 3083548
ChemSpider 2340735 YesY
Chemical data
Formula C19H24N2O
Molecular mass 296.407 g/mol
 N (what is this?)  (verify)

Noribogaine, or 12-hydroxyibogamine, is the principal psychoactive metabolite of the psychedelic drug ibogaine. It is thought to be involved in the anti-addictive effects of ibogaine-containing plant extracts.[1][2][3]

A recent study evaluated its effects on healthy volunteers at doses of 3–60 mg, finding no tolerability issues.[4] A slow half-life of 28–49 hours was seen with large volume of distribution.


Noribogaine inhibits serotonin uptake more than ibogaine but does not affect dopamine.[5] It has greater affinity for serotonin transporters and less at sigma-2 receptors. In binding studies noribogaine has a greater affinity at each opioid receptor than ibogaine.

Ki-values in μM[6]

Recetor Noribogaine
κ-opioid 0.96
μ-opioid 2.66
δ-opioid 24.7

See also[edit]


  1. ^ Glick SD, Maisonneuve IS (May 1998). "Mechanisms of antiaddictive actions of ibogaine". Annals of the New York Academy of Sciences 844: 214–26. doi:10.1111/j.1749-6632.1998.tb08237.x. PMID 9668680. 
  2. ^ Baumann MH, Pablo J, Ali SF, Rothman RB, Mash DC (2001). "Comparative neuropharmacology of ibogaine and its O-desmethyl metabolite, noribogaine". The Alkaloids. Chemistry and Biology 56: 79–113. doi:10.1016/S0099-9598(01)56009-5. PMID 11705118. 
  3. ^ Kubiliene A, Marksiene R, Kazlauskas S, Sadauskiene I, Razukas A, Ivanov L (2008). "Acute toxicity of ibogaine and noribogaine". Medicina (Kaunas, Lithuania) 44 (12): 984–8. PMID 19142057. 
  4. ^ "Ascending-dose study of noribogaine in healthy volunteers: Pharmacokinetics, pharmacodynamics, safety, and tolerability.". The Journal of Clinical Pharmacology 55: 189–94. Oct 3, 2014. doi:10.1002/jcph.404. PMID 25279818. 
  5. ^ Baumann, Michael H.; Rothman, Richard B.; Pablo, John P.; Mash, Deborah C. (05/01/2001). "In Vivo Neurobiological Effects of Ibogaine and Its O-Desmethyl Metabolite, 12-Hydroxyibogamine (Noribogaine), in Rats". Journal of Pharmacology and Experimental Therapeutics 297 (2): 531–539. ISSN 1521-0103. PMID 11303040.  Check date values in: |date= (help)
  6. ^ Pearl, S. M.; Herrick-Davis, K.; Teitler, M.; Glick, S. D. (Mar 27, 1995). "Radioligand-binding study of noribogaine, a likely metabolite of ibogaine". Brain Research 675 (1-2): 342–344. ISSN 0006-8993. PMID 7796150.