3D model (JSmol)
|Molar mass||201.31 g·mol−1|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
PD-137889 (N-methylhexahydrofluorenamine) is a chemical compound that is active as an NMDA receptor antagonist in the central nervous system at roughly 30 times the potency of the "flagship" of its class, ketamine, and substitutes for phencyclidine in animal studies. It has a putative half-life of over ten hours. Ki [3H]TCP[a] binding = 27 nM versus ketamine's Ki = 860 nM.
- "Synthesis and pharmacological evaluation of hexahydrofluorenamines as noncompetitive antagonists at the N-methyl-D-aspartate receptor". J Med Chem. 36 (6): 654–70. 1993. doi:10.1021/jm00058a002. PMID 8459395.
- Nicholson KL, Balster RL. Evaluation of the phencyclidine-like discriminative stimulus effects of novel NMDA channel blockers in rats. Psychopharmacology (Berl). 2003 Nov;170(2):215-24. PMID 12851738 doi: 10.1007/s00213-003-1527-6
- Bigge CF. Structural requirements for the development of potent N-methyl-D-aspartic acid (NMDA) receptor antagonists. Biochemical Pharmacology 1993; 45(8):1547–1561. doi:10.1016/0006-2952(93)90294-7
- Bigge CF, Malone TC. Agonists, Antagonists and Modulators of the N-methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) Subtypes of Glutamate Receptors. Current Opinion On Therapeutic Patents 1993; 3(7):951-989. doi: 10.1517/135437184.108.40.2061
- Polycyclic amine derivatives useful as cerebrovascular agents United States Patent; Coughenour, et al. Family ID: 22686445 Appl. #07/186,834
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