Systematic (IUPAC) name
ATC code none
C 21 H 26 N 2 O 2
Molar mass 338.44 g/mol
Coronaridine, also known as 18-carbomethoxyibogamine, is an alkaloid found in and related species,including Tabernanthe iboga for which (under the now obsolete synonym Tabernaemontana divaricata Ervatamia coronaria) it was named. 
Coronaridine persistently reduces the self-administration of cocaine and morphine in rats.
Pharmacology [ edit ]
Coronaridine has been reported to bind to an assortment of molecular sites, including:
μ-opioid (K i = 2.0 μM), δ-opioid (K i = 8.1 μM), and κ-opioid receptors (K i = 4.3 μM), NMDA receptor (K i = 6.24 μM) (as an antagonist), and  nAChRs (as an antagonist). It has also been found to inhibit the enzyme  acetylcholinesterase, act as a voltage-gated sodium channel blocker, and displays  estrogenic activity in rodents.  In contrast to  ibogaine and other iboga alkaloids, coronaridine does not bind to either the σ or 1 σ. 2 receptor Coronaridine also has  estrogenic properties. 
See also [ edit ]
References [ edit ]
^ Delorenzi JC, Freire-de-Lima L, Gattass CR, et al. (July 2002). "In vitro activities of iboga alkaloid congeners coronaridine and 18-methoxycoronaridine against Leishmania amazonensis". Antimicrobial Agents and Chemotherapy. 46 (7): 2111–5. doi: 10.1128/aac.46.7.2111-2115.2002. PMC 127312 . PMID 12069962.
^ Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW Jr, Carlson JN (September 1994). "Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum.". Brain Res. 657 (1-2): 14–22. doi: 10.1016/0006-8993(94)90948-2. PMID 7820611.
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