Ibogamine

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Ibogamine
Skeletal formula of ibogamine
Ball-and-stick model of the ibogamine molecule
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
ChEBI
Chemical and physical data
Formula C19H24N2
Molar mass 280.41 g/mol
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Ibogamine is an alkaloid found in Tabernanthe iboga.[1][2]

Basic research related to how addiction affects the brain has used this chemical.[3]

Ibogamine persistently reduced the self-administration of cocaine and morphine in rats.[4]

See also[edit]

References[edit]

  1. ^ Bartlett, M. F.; Dickel, D. F.; Taylor, W. I. (1958). "The Alkaloids of Tabernanthe iboga. Part IV.1 The Structures of Ibogamine, Ibogaine, Tabernanthine and Voacangine - Journal of the American Chemical Society (ACS Publications)". Journal of the American Chemical Society. 80 (1): 126–136. doi:10.1021/ja01534a036. 
  2. ^ Kuehne, Martin E.; Reider, Paul J. (1985). "A synthesis of ibogamine - The Journal of Organic Chemistry (ACS Publications)". The Journal of Organic Chemistry. 50 (9): 1464–1467. doi:10.1021/jo00209a020. 
  3. ^ Levi MS, Borne RF (October 2002). "A review of chemical agents in the pharmacotherapy of addiction". Curr. Med. Chem. 9 (20): 1807–18. PMID 12369879. doi:10.2174/0929867023368980. 
  4. ^ Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW Jr, Carlson JN (September 1994). "Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum.". Brain Res. 657 (1-2): 14–22. PMID 7820611. doi:10.1016/0006-8993(94)90948-2.