Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral glycoproteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. Dna templated transcription, with some alternative splicing mechanism is the method of transcription. Translation takes place by leaky scanning. The virus exits the host cell by nuclear pore export, and existing in occlusion bodies after cell death and remaining infectious until finding another host. Winged insects, arthropods, lepidoptora, hymenoptera, diptera, and decapoda serve as the natural host. Transmission routes are fecal-oral.
Midgut then hemocoel; digestive gland epithelium (shrimps)