Phosphoenolpyruvate—protein phosphotransferase
| phosphoenolpyruvate-protein phosphotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.3.9 | ||||||||
| CAS no. | 37278-17-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) is an enzyme that catalyzes the chemical reaction
- phosphoenolpyruvate + protein histidine pyruvate + protein Npi-phospho-L-histidine
Thus, the two substrates of this enzyme are phosphoenolpyruvate and protein histidine, whereas its two products are pyruvate and protein Npi-phospho-L-histidine.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a nitrogenous group as acceptor. The systematic name of this enzyme class is phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase. Other names in common use include phosphoenolpyruvate sugar phosphotransferase enzyme I, phosphopyruvate-protein factor phosphotransferase, phosphopyruvate-protein phosphotransferase, sugar-PEP phosphotransferase enzyme I, and phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase. This enzyme participates in phosphotransferase system (pts).
Structural studies
As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1EZA, 1EZB, 1EZC, 1EZD, 1ZYM, 2EZA, 2EZB, 2EZC, 2HRO, 2HWG, 3EZA, 3EZB, and 3EZE.
References
- "The bacterial phosphoenolpyruvate: sugar phosphotransferase system". Biochim. Biophys. Acta. 457 (3–4): 213–57. 1976. doi:10.1016/0304-4157(76)90001-0. PMID 187249.