Streptomycin 3"-adenylyltransferase
streptomycin 3-adenylyltransferase | |||||||||
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Identifiers | |||||||||
EC no. | 2.7.7.47 | ||||||||
CAS no. | 52660-23-8 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a streptomycin 3"-adenylyltransferase (EC 2.7.7.47) is an enzyme that catalyzes the chemical reaction
- ATP + streptomycin diphosphate + 3"-adenylylstreptomycin
Thus, the two substrates of this enzyme are ATP and streptomycin, whereas its two products are diphosphate and 3''-adenylylstreptomycin.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:streptomycin 3"-adenylyltransferase. Other names in common use include streptomycin adenylate synthetase, streptomycin adenyltransferase, streptomycin adenylylase, streptomycin adenylyltransferase, streptomycin-spectinomycin adenylyltransferase, AAD (3"), and aminoglycoside 3"-adenylyltransferase.
References
- Harwood JH, Smith DH (1969). "Resistance factor-mediated streptomycin resistance". J. Bacteriol. 97 (3): 1262–71. PMC 249843. PMID 4887506.