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Several special routes of U.S. Route 6 exist. In order from west to east they are as follows.
Price business loop
U.S. Route 6 Business (US-6 Bus.) is a short highway that loops around the town of Price in central Utah, beginning and ending at US-6/US-191 in a span of 3 miles (4.8 km). SR-55 is cosigned with the route.
Western Greater Cleveland alternate route
U.S. Route 6 Alternate (US 6 Alt.) is an east–west alternate route of US 6 located in Greater Cleveland, Ohio, traveling 7.3 miles (11.7 km). Its western terminus is at US 6 in Rocky River, Ohio, just west of the Rocky River, overlapping US 6's connection with SR 2; its eastern terminus is just west of the Cuyahoga River in the Ohio City neighborhood of Cleveland. US 20 and SR 113 travel concurrent with US 6 Alt. for 0.2 miles (0.32 km) while they cross the Rocky River. Nearly all of its 7-mile (11 km) span follows Detroit Avenue's alignment through Lakewood and Cleveland, which also carried US 20 Alt. for a time. The far western portion in Rocky River follows Detroit Road and Old Lake Road.
US 6 Alt. exists to provide a route for truck traffic, as commercial vehicles are prohibited on Clifton Boulevard.
Warren business loop
U.S. Route 6 Business (US 6 Bus.) is a 4-mile (6.4 km) loop through the city center of Warren, Pennsylvania. In 1989, a freeway bypass for US 6 was completed on the southside of the Allegheny River, while the original routing plus a connecting bridge were designated as a business loop. Except for brief stay as Ludlow Street near its western terimus, the route mostly follows Pennsylvania Avenue. It is cosigned with US 62 for approximately the westernmost 1 mile (1.6 km) of its route.
The entire route is in Warren County.
Tunkhannock business loop
U.S. Route 6 Business (US 6 Bus.) is a 2-mile-long (3.2 km) loop through the borough of Tunkhannock, Pennsylvania. The route was signed in 2000, as a wider (but still two-lane) by-pass was constructed along the Susquehanna River to avoid the narrow old alignment. The business loop consists of Tioga Street, the main artery of the town.
The entire route is in Wyoming County.
Scranton–Carbondale business loop
U.S. Route 6 Business (US 6 Bus.) is a 14-mile-long (23 km) loop through northern suburbs of the city of Scranton, Pennsylvania. The route was formed in 1999, after a freeway bypass was constructed. The route begins as a four-lane undivided highway, featuring a variety of businesses but avoiding the centers of suburbs like Dickson City and Blakely. It then becomes a two-lane route and skirts north of the narrow suburban finger by traveling through Archbald Pothole State Park and Pennsylvania forestry land. Upon entering Carbondale, the route dips south back into suburban development and serves as a narrow two-lane street for the remainder of its route.
The entire route is in Lackawanna County.
Garrison-Peekskill alternate route
Beginning at where US 6/US 202 meet NY 9D at the eastern foot of the Bear Mountain Bridge, U.S. Route 6/202 Alternate (US 6/202 Alt.) is a 10.5-mile (16.9 km) signed bypass of the segment of US 6/US 202 known as Bear Mountain Bridge Road, a sharply winding route to US 9 in Peekskill. US 6/202 Alt. follows NY 9D north to NY 403, then US 9 south, ending at the US 6/US 9/US 202 traffic circle. This bypass is an important route for commercial vehicles which cannot traverse Bear Mountain Bridge Road, though they are permitted to do so.
In Scituate, US 6 splits into U.S. Route 6 Bypass (US 6 Byp.) and U.S. Route 6 Business (US 6 Bus.). The business alignment travels further south along the old turnpike, and is mostly signed as US 6 without a banner. The bypass is signed mostly as BY-PASS US 6 on sign assemblies but as bannerless US 6 on green guide signs. Most maps and information takes US 6 along the bypass.
The business and bypass cross Route 102 soon after splitting. The western half of the bypass is a two-lane limited access road, with one grade separation — under Gleaner Chapel Road — and one intersection — at Route 102. This newer section ends as it merges with Route 101, once the Rhode Island and Connecticut Turnpike, and now called Hartford Pike. The two parallel alignments cross the Scituate Reservoir and Route 116 before they merge near the east edge of Scituate. This merge was the east end of the Foster and Scituate Turnpike, and was the east end of Route 101 until the early 2000s (when it was truncated to the merge with US 6 Byp.). The Rhode Island and Connecticut Turnpike continued to the Olneyville section of Providence, where it is known as Hartford Avenue.
Rhode Island alternate route
U.S. Route 6A (US 6A) is an alternate route of US 6 in Rhode Island. The route begins at US 6 and I-295 in Johnston and follows Hartford Avenue 2.5 miles (4.0 km) through the city. US 6A continues into Providence, traveling 1.1 miles (1.8 km) along Hartford Avenue to its terminus at US 6.
US 6A previously carried mainline US 6 until around 1990, when the US 6 designation was moved to the Dennis J. Roberts Expressway replacing the expressway's previous designation of Route 195.
U.S. Route 6 Bypass (US 6 Byp.) exists in Bourne, Massachusetts, where the mainline of US 6 is on the other side of the Cape Cod Canal. However, it is not well signed, and this stretch of road is commonly referred to as Sandwich Road.
Lansing–Lake Station business loop
Business U.S. 6 follows along Ridge Road, the former alignment of U.S. 6 before the route was moved to the Borman Expressway which also carries Interstate 80 and Interstate 94 through the cities of Northwest Indiana. The route begins in Lansing, Illinois and heads east across the state line into Munster, Indiana and travels through Highland, Griffith, the southern part of Gary, and Hobart (where the road is marked as "37th Avenue"). The route ends in Hobart at the intersection of U.S. 6, SR 51 and SR 130.
Eastern Greater Cleveland alternate route
U.S. Route 6 Alternate (US 6 Alt.) traveled along Euclid Avenue, with US 20 Alt., in Cleveland and East Cleveland from 1936 until 1967, when US 20 was removed from US 6 and routed along Euclid Avenue from Superior Avenue in East Cleveland to Public Square in Cleveland.
Union City bypass
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Newtown–Southbury alternate route
U.S. Route 6A (US 6A) between Newtown and Southbury was the original surface routing of US 6 before the formation of expressway that later became I-84; currently Route 816.
Plymouth–Hartford alternate route
U.S. Route 6A (US 6A) between Plymouth and Hartford is currently US 6. At this time, the old US 6 went along Route 64 to downtown Waterbury then along Route 10 to Farmington.
Woodbury–Willimantic alternate route
U.S. Route 6A (US 6A) originally connected Woodbury to Willimantic. West of Meriden, this was the original alignment of US 6. When US 6 was reassigned to the former US 6A from Plymouth–Farmington, this became US 6A. This US 6A was subsequently extended through Meriden to Willimantic along modern Route 66. An expressway upgrade was planned for this US 6A. Only a portion of the highway was built and is now I-691.
Coventry–Windham alternate route
U.S. Route 6A (US 6A) between Coventry and Windham was designated when New England Interstate Route 3 (NE-3) was deleted. The route was swapped with the old US 6 in 1939 and finally deleted in 1942 when US 6A became Route 31.
Danielson alternate route
U.S. Route 6A (US 6A) in Danielson was the old routing of US 6 prior to construction of the two-lane freeway.
Oglesby, Scott. "Connecticut US 6A". Connecticut Roads. Kurumi. Retrieved 1 August 2015.