UGT1A3

UGT1A3
Identifiers
Aliases	UGT1A3, UDPGT, UDPGT 1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C, UGT1A3S, UDP glucuronosyltransferase family 1 member A3
External IDs	OMIM: 606428 MGI: 3576049 HomoloGene: 86211 GeneCards: UGT1A3
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,773,300 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	88,146,719 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; muscle tissue; ; kidney; ; small intestine; ; duodenum; ; colon;
	Top expressed in
	kidney; ; renal cortex; ; liver; ; duodenum; ; lip; ; uterus; ; bone marrow; ; proximal tubule; ; jejunum; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; retinoic acid binding; hexosyltransferase activity; protein homodimerization activity; glycosyltransferase activity; glucuronosyltransferase activity; protein heterodimerization activity; enzyme binding; UDP-glycosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum;
Biological process	retinoic acid metabolic process; negative regulation of cellular glucuronidation; cellular glucuronidation; flavonoid glucuronidation; xenobiotic glucuronidation; negative regulation of glucuronosyltransferase activity; negative regulation of fatty acid metabolic process; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	54659
	22236
	ENSG00000288702
	ENSMUSG00000090171
	P35503
	P70691
	NM_019093
	NM_013701
	NP_061966
	NP_038729
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronosyltransferase 1-3 is an enzyme that in humans is encoded by the UGT1A3 gene.^[5]^[6]^[7]^[8]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000288702 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090171 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (Oct 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054.
^ Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (Mar 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J Biol Chem. 267 (5): 3257–61. PMID 1339448.
^ Gong QH, Cho JW, Huang T, Potter C, Gholami N, Basu NK, Kubota S, Carvalho S, Pennington MW, Owens IS, Popescu NC (Jul 2001). "Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus". Pharmacogenetics. 11 (4): 357–68. doi:10.1097/00008571-200106000-00011. PMID 11434514.
^ "Entrez Gene: UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3".

References

Further reading