Tyrosine-protein kinase Yes

YES1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HDA
Identifiers
Aliases	YES1, HsT441, P61-YES, Yes, c-yes, YES proto-oncogene 1, Src family tyrosine kinase
External IDs	OMIM: 164880; MGI: 99147; HomoloGene: 55900; GeneCards: YES1; OMA:YES1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	812,546 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	32,844,401 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; jejunal mucosa; ; parotid gland; ; buccal mucosa cell; ; visceral pleura; ; gingival epithelium; ; parietal pleura; ; endothelial cell; ; corpus epididymis; ; lactiferous duct;
	Top expressed in
	lumbar spinal ganglion; ; cumulus cell; ; left lung lobe; ; tail of embryo; ; migratory enteric neural crest cell; ; seminal vesicula; ; Rostral migratory stream; ; genital tubercle; ; Gonadal ridge; ; zygote;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; transmembrane transporter binding; epidermal growth factor receptor binding; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein binding; enzyme binding; protein tyrosine kinase activity; signaling receptor binding; ATP binding; phosphotyrosine residue binding;
Cellular component	Golgi apparatus; membrane; focal adhesion; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; microtubule organizing center; actin filament; extracellular exosome; cytoskeleton; cytoplasm; cytosol; glutamatergic synapse; postsynaptic specialization, intracellular component;
Biological process	cellular response to transforming growth factor beta stimulus; cellular response to retinoic acid; cell differentiation; Fc-gamma receptor signaling pathway involved in phagocytosis; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; ephrin receptor signaling pathway; T cell costimulation; cellular response to platelet-derived growth factor stimulus; protein phosphorylation; regulation of vascular permeability; regulation of cell population proliferation; positive regulation of peptidyl-tyrosine phosphorylation; peptidyl-tyrosine autophosphorylation; protein autophosphorylation; leukocyte migration; positive regulation of transcription by RNA polymerase II; innate immune response; cell migration; regulation of glucose transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	7525
	22612
	ENSG00000176105
	ENSMUSG00000014932
	P07947
	Q04736
	NM_005433
	NM_001205132; NM_001205133; NM_009535
	NP_005424
	NP_001192061; NP_001192062; NP_033561
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene tyrosine-protein kinase Yes is an enzyme that in humans is encoded by the YES1 gene.^[5]^[6]

Template:PBB Summary

Interactions

YES1 has been shown to interact with Janus kinase 2,^[7] CTNND1,^[8] RPL10^[9] and Occludin.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176105 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000014932 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Semba K, Yamanashi Y, Nishizawa M, Sukegawa J, Yoshida M, Sasaki M, Yamamoto T, Toyoshima K (Mar 1985). "Location of the c-yes gene on the human chromosome and its expression in various tissues". Science. 227 (4690): 1038–40. doi:10.1126/science.2983418. PMID 2983418.
^ "Entrez Gene: YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1".
^ Fuhrer, D K; Yang Y C (Jul 1996). "Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11". Biochem. Biophys. Res. Commun. 224 (2). UNITED STATES: 289–96. doi:10.1006/bbrc.1996.1023. ISSN 0006-291X. PMID 8702385. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)
^ Piedra, Jose; Miravet Susana; Castaño Julio; Pálmer Héctor G; Heisterkamp Nora; García de Herreros Antonio; Duñach Mireia (Apr 2003). "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction". Mol. Cell. Biol. 23 (7). United States: 2287–97. doi:10.1128/MCB.23.7.2287-2297.2003. ISSN 0270-7306. PMC 150740. PMID 12640114. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Oh, Hyung Suk; Kwon Haeyoung; Sun Suk Kyun; Yang Chul-Hak (Sep 2002). "QM, a putative tumor suppressor, regulates proto-oncogene c-yes". J. Biol. Chem. 277 (39). United States: 36489–98. doi:10.1074/jbc.M201859200. ISSN 0021-9258. PMID 12138090. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Chen, Yan-Hua; Lu Qun; Goodenough Daniel A; Jeansonne Beverly (Apr 2002). "Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells". Mol. Biol. Cell. 13 (4). United States: 1227–37. doi:10.1091/mbc.01-08-0423. ISSN 1059-1524. PMC 102264. PMID 11950934. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading