60S ribosomal protein L10

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RPL10
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RPL10, AUTSX5, DXS648, DXS648E, L10, NOV, QM, ribosomal protein L10
External IDs MGI: 105943 HomoloGene: 130545 GeneCards: RPL10
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_052835

RefSeq (protein)

NP_443067.1
NP_443067

Location (UCSC) Chr X: 154.39 – 154.41 Mb Chr X: 74.27 – 74.27 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L10 is a protein that in humans is encoded by the RPL10 gene.[3][4]

Function[edit]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as 'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Transcript variants utilizing alternative polyA signals exist. The variant with the longest 3' UTR overlaps the deoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[4]

Interactions[edit]

RPL10 has been shown to interact with YES1.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194. 
  4. ^ a b "Entrez Gene: RPL10 ribosomal protein L10". 
  5. ^ Oh HS, Kwon H, Sun SK, Yang CH (September 2002). "QM, a putative tumor suppressor, regulates proto-oncogene c-yes". J. Biol. Chem. 277 (39): 36489–98. doi:10.1074/jbc.M201859200. PMID 12138090. 

Further reading[edit]