Disulfiram-like drug: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
No edit summary
Line 13: Line 13:
}}
}}


A '''disulfiram-like drug''' is a drug that causes [[hypersensitivity]] to the [[acetaldehyde]]-mediated [[adverse effect|unpleasant]] and [[toxicity|toxic]] effects of [[alcohol (drug)|alcohol]].<ref name="MarxWalls2013" /><ref name="pmid9260032">{{cite journal | vauthors = Fraser AG | title = Pharmacokinetic interactions between alcohol and other drugs | journal = Clin Pharmacokinet | volume = 33 | issue = 2 | pages = 79–90 | year = 1997 | pmid = 9260032 | doi = 10.2165/00003088-199733020-00001 | url = }}</ref><ref name="BorjaOliveira2014">{{cite journal|last1=Borja Oliveira|first1=Caroline R|title=Alcohol-Medication Interactions: The Acetaldehyde Syndrome|journal=J Pharmacovigilance|volume=2|issue=5|year=2014|issn=23296887|doi=10.4172/2329-6887.1000145|url=http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.969.771&rep=rep1&type=pdf}}</ref> Such effects may include [[nausea]], [[vomiting]], [[alcohol flush reaction|flushing]], [[dizziness]], throbbing [[headache]], [[chest pain|chest]] and [[abdominal pain|abdominal discomfort]], and general [[hangover]]-like [[symptom]]s among others.<ref name="MarxWalls2013" /><ref name="pmid9260032" /><ref name="BorjaOliveira2014" /> This reaction has been variously termed a ''disulfiram-like reaction'', ''alcohol intolerance'', and ''acetaldehyde syndrome''.<ref name="MutalikSanghavi2014">Mutalik, M., & Sanghavi, D. (2014). Review of Drug Interactions: A Comprehensive Update.</ref><ref name="BorjaOliveira2014" />
A '''disulfiram-like drug''' is a drug that causes [[hypersensitivity]] to the [[adverse effect|unpleasant]] and [[toxicity|toxic]] effects of [[alcohol (drug)|alcohol]].<ref name="MarxWalls2013" /><ref name="pmid9260032">{{cite journal | vauthors = Fraser AG | title = Pharmacokinetic interactions between alcohol and other drugs | journal = Clin Pharmacokinet | volume = 33 | issue = 2 | pages = 79–90 | year = 1997 | pmid = 9260032 | doi = 10.2165/00003088-199733020-00001 | url = }}</ref><ref name="BorjaOliveira2014">{{cite journal|last1=Borja Oliveira|first1=Caroline R|title=Alcohol-Medication Interactions: The Acetaldehyde Syndrome|journal=J Pharmacovigilance|volume=2|issue=5|year=2014|issn=23296887|doi=10.4172/2329-6887.1000145|url=http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.969.771&rep=rep1&type=pdf}}</ref> Such effects may include [[nausea]], [[vomiting]], [[alcohol flush reaction|flushing]], [[dizziness]], throbbing [[headache]], [[chest pain|chest]] and [[abdominal pain|abdominal discomfort]], and general [[hangover]]-like [[symptom]]s among others.<ref name="MarxWalls2013" /><ref name="pmid9260032" /><ref name="BorjaOliveira2014" /> They are caused by accumulation of [[acetaldehyde]], a major but toxic [[metabolite]] of alcohol formed by the [[enzyme]] [[alcohol dehydrogenase]].<ref name="MarxWalls2013" /><ref name="pmid9260032" /><ref name="BorjaOliveira2014" /> The reaction has been variously termed a ''disulfiram-like reaction'', ''alcohol intolerance'', and ''acetaldehyde syndrome''.<ref name="MutalikSanghavi2014">Mutalik, M., & Sanghavi, D. (2014). Review of Drug Interactions: A Comprehensive Update.</ref><ref name="BorjaOliveira2014" />


The prototypical drug of this group is [[disulfiram]] (brand name Antabuse), which acts as an [[acetaldehyde dehydrogenase]] [[enzyme inhibitor|inhibitor]] and is used in the treatment of [[alcoholism]].<ref name="MarxWalls2013" /><ref name="pmid9260032" /><ref name="BorjaOliveira2014" /> Many other drugs cause disulfiram-like reactions upon consumption of alcohol as unintended [[drug interaction]]s and [[side effect]]s.<ref name="MarxWalls2013" /><ref name="pmid9260032" /><ref name="BorjaOliveira2014" /> Many disulfiram-like drugs act as inhibitors of acetaldehyde dehydrogenase similarly to disulfiram.<ref name="BorjaOliveira2014" /> However, some do not act via inhibition of this [[enzyme]] and instead act via other, poorly elucidated [[mechanism of action|mechanism]]s.<ref name="BorjaOliveira2014" />
The prototypical drug of this group is [[disulfiram]] (brand name Antabuse), which acts as an [[acetaldehyde dehydrogenase]] [[enzyme inhibitor|inhibitor]], preventing the metabolism of acetaldehyde into [[acetic acid]], and is used in the treatment of [[alcoholism]].<ref name="MarxWalls2013" /><ref name="pmid9260032" /><ref name="BorjaOliveira2014" /> A variety of other drugs cause disulfiram-like reactions upon consumption of alcohol as unintended [[drug interaction]]s and [[side effect]]s.<ref name="MarxWalls2013" /><ref name="pmid9260032" /><ref name="BorjaOliveira2014" /> Many disulfiram-like drugs act as inhibitors of acetaldehyde dehydrogenase similarly to disulfiram.<ref name="BorjaOliveira2014" /> However, some do not act via inhibition of this [[enzyme]], and instead act via other, poorly elucidated [[mechanism of action|mechanism]]s.<ref name="BorjaOliveira2014" />

Unlike acetaldehyde dehydrogenase inhibitors and other disulfiram-like drugs, [[alcohol dehydrogenase]] inhibitors such as [[fomepizole]] (brand name Antizol) inhibit the [[metabolism]] of alcohol into acetaldehyde, thereby increasing and extending the effects of alcohol and reducing its toxicity.<ref name="pmid26551875">{{cite journal | vauthors = McMartin K, Jacobsen D, Hovda KE | title = Antidotes for poisoning by alcohols that form toxic metabolites | journal = Br J Clin Pharmacol | volume = 81 | issue = 3 | pages = 505–15 | year = 2016 | pmid = 26551875 | pmc = 4767193 | doi = 10.1111/bcp.12824 | url = }}</ref> As such, they can be thought of as converses of disulfiram-like drugs.<ref name="pmid26551875" /> Fomepizole is used medically as an [[antidote]] against [[methanol]] and [[ethylene glycol]] [[poisoning]].<ref name="pmid26551875" />


==List of agents==
==List of agents==

Revision as of 07:22, 18 September 2017

Disulfiram-like drug
Drug class
Disulfiram, the prototypical drug of this class.
Class identifiers
SynonymsAlcohol sensitizers; Alcohol-sensitizing agents; Alcohol-deterrent drugs; Acetaldehyde dehydrogenase inhibitors
UseAlcoholism
Biological targetAcetaldehyde dehydrogenase, others
Legal status
In Wikidata

A disulfiram-like drug is a drug that causes hypersensitivity to the unpleasant and toxic effects of alcohol.[1][2][3] Such effects may include nausea, vomiting, flushing, dizziness, throbbing headache, chest and abdominal discomfort, and general hangover-like symptoms among others.[1][2][3] They are caused by accumulation of acetaldehyde, a major but toxic metabolite of alcohol formed by the enzyme alcohol dehydrogenase.[1][2][3] The reaction has been variously termed a disulfiram-like reaction, alcohol intolerance, and acetaldehyde syndrome.[4][3]

The prototypical drug of this group is disulfiram (brand name Antabuse), which acts as an acetaldehyde dehydrogenase inhibitor, preventing the metabolism of acetaldehyde into acetic acid, and is used in the treatment of alcoholism.[1][2][3] A variety of other drugs cause disulfiram-like reactions upon consumption of alcohol as unintended drug interactions and side effects.[1][2][3] Many disulfiram-like drugs act as inhibitors of acetaldehyde dehydrogenase similarly to disulfiram.[3] However, some do not act via inhibition of this enzyme, and instead act via other, poorly elucidated mechanisms.[3]

Unlike acetaldehyde dehydrogenase inhibitors and other disulfiram-like drugs, alcohol dehydrogenase inhibitors such as fomepizole (brand name Antizol) inhibit the metabolism of alcohol into acetaldehyde, thereby increasing and extending the effects of alcohol and reducing its toxicity.[5] As such, they can be thought of as converses of disulfiram-like drugs.[5] Fomepizole is used medically as an antidote against methanol and ethylene glycol poisoning.[5]

List of agents

Intended

Drugs which cause disulfiram-like reactions upon ingestion of alcohol as an intended effect include:[6][3]

Unintended

Drugs which cause disulfiram-like reactions upon ingestion of alcohol as an unintended effect include:[7][1][8][3]

Natural

Natural compounds and species which have been found to cause disulfiram-like reactions upon ingestion of alcohol include:[11][12]

See also

References

  1. ^ a b c d e f John Marx; Ron Walls; Robert Hockberger (1 August 2013). Rosen's Emergency Medicine - Concepts and Clinical Practice E-Book. Elsevier Health Sciences. pp. 2398–. ISBN 978-1-4557-4987-4.
  2. ^ a b c d e Fraser AG (1997). "Pharmacokinetic interactions between alcohol and other drugs". Clin Pharmacokinet. 33 (2): 79–90. doi:10.2165/00003088-199733020-00001. PMID 9260032.
  3. ^ a b c d e f g h i j Borja Oliveira, Caroline R (2014). "Alcohol-Medication Interactions: The Acetaldehyde Syndrome". J Pharmacovigilance. 2 (5). doi:10.4172/2329-6887.1000145. ISSN 2329-6887.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  4. ^ Mutalik, M., & Sanghavi, D. (2014). Review of Drug Interactions: A Comprehensive Update.
  5. ^ a b c McMartin K, Jacobsen D, Hovda KE (2016). "Antidotes for poisoning by alcohols that form toxic metabolites". Br J Clin Pharmacol. 81 (3): 505–15. doi:10.1111/bcp.12824. PMC 4767193. PMID 26551875.
  6. ^ Helmut K. Seitz; B. Kommerell (6 December 2012). Alcohol Related Diseases in Gastroenterology. Springer Science & Business Media. pp. 175–. ISBN 978-3-642-70048-4.
  7. ^ Amitava Dasgupta (17 October 2016). Alcohol, Drugs, Genes and the Clinical Laboratory: An Overview for Healthcare and Safety Professionals. Elsevier Science. pp. 77–. ISBN 978-0-12-809334-4.
  8. ^ Reginald Smart (22 November 2013). Research Advances in Alcohol and Drug Problems. Springer Science & Business Media. pp. 399–. ISBN 978-1-4613-3626-6.
  9. ^ Kitson TM (1987). "The effect of cephalosporin antibiotics on alcohol metabolism: a review". Alcohol. 4 (3): 143–8. PMID 3593530.
  10. ^ Lewis R. Goldfrank (2006). Goldfrank's Toxicologic Emergencies (PDF). McGraw Hill Professional. ISBN 978-0-07-147914-1.
  11. ^ Joseph F. Ammirati (1985). Poisonous Mushrooms of the Northern United States and Canada. U of Minnesota Press. pp. 131–. ISBN 978-0-8166-1407-3.
  12. ^ Barry H. Rumack; David G. Spoerke (27 September 1994). Handbook of Mushroom Poisoning: Diagnosis and Treatment. CRC Press. pp. 303–. ISBN 978-0-8493-0194-0.


Retrieved from "https://en.wikipedia.org/w/index.php?title=Disulfiram-like_drug&oldid=801195544"