Amsacrine

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Amsacrine
Amsacrine.svg
Systematic (IUPAC) name
N-(4-(acridin-9-ylamino)-3-methoxyphenyl)methanesulfonamide
Clinical data
Legal status ?
Pharmacokinetic data
Protein binding 96 to 98%
Half-life 8-9 hours
Identifiers
CAS number 51264-14-3 YesY
ATC code L01XX01
PubChem CID 2179
DrugBank DB00276
ChemSpider 2094 YesY
UNII 00DPD30SOY YesY
KEGG D02321 YesY
ChEBI CHEBI:2687 YesY
ChEMBL CHEMBL43 YesY
Chemical data
Formula C21H19N3O3S 
Mol. mass 393.46 g/mol
 YesY (what is this?)  (verify)

Amsacrine (synonyms: m-AMSA, acridinyl anisidide) is an antineoplastic agent.

It has been used in acute lymphoblastic leukemia.[1]

Mechanism[edit]

Its planar fused ring system can intercalate into the DNA of tumor cells, thereby altering the major and minor groove proportions. These alterations to DNA structure inhibit both DNA replication and transcription by reducing association between the affected DNA and: DNA polymerase, RNA polymerase and transcription factors.

Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II (compares with the better known agent etoposide).[2] In contrast, the structurally similar o-AMSA differing in the position of the methoxy substituent group on the anilino-ring have little ability to poison topoisomerase II despite of its intercalative behavior, suggesting that intercalation of the molecule in itself is insufficient to trap topoisomerase II as a covalent complex on DNA. [3] [4] [5]

References[edit]

  1. ^ "Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children". Haematologica 90 (12): 1701–3. December 2005. PMID 16330449. 
  2. ^ Genetic Response to Metals. Sarkar, Bibudhendra. CRC Press, 1995. ISBN 978-0-8247-9615-0
  3. ^ "Thermodynamics of the interactions of m-AMSA and o-AMSA with nucleic acids: influence of ionic strength and DNA base composition". Nucleic Acids Res. 17 (23): 9933–46. December 1989. doi:10.1093/nar/17.23.9933. PMC 335223. PMID 2602146. 
  4. ^ "Mutagenicity of m-AMSA and o-AMSA in mammalian cells due to clastogenic mechanism: possible role of topoisomerase". Mutagenesis 2 (5): 349–55. September 1987. PMID 2830452. 
  5. ^ "Targeting DNA topoisomerase II in cancer chemotherapy". Nat. Rev. Cancer 9 (5): 338–50. May 2009. doi:10.1038/nrc2607. PMC 2748742. PMID 19377506.