Lomustine (or "CCNU")(Marketed under the name CeeNU in US) is an alkylating nitrosourea compound used in chemotherapy. It is in the same family as streptozotocin. This is a highly lipid soluble drug, and thus crosses the blood brain barrier. This property makes it ideal for treating brain tumors, and is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).
Adults: 100-150mg/m2 PO every 6 weeks (subsequent dose based on WBC)  Cats (7,5 kg): 15mg every 6 weeks Dogs: 60-90mg/m^2 every 3 weeks.
Dosage Form 
10mg, 15mg, 40mg, 100mg Capsules
It is the "C" in the "PCV" chemotherapy regimen.
- ^ Lexi-Comp Drug Information Handbook
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