Lomustine
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| Systematic (IUPAC) name | |
|---|---|
| N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea | |
| Clinical data | |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a682207 |
| Pregnancy cat. | D |
| Legal status | ? |
| Routes | Oral |
| Pharmacokinetic data | |
| Protein binding | 50% |
| Identifiers | |
| CAS number | 13010-47-4 |
| ATC code | L01AD02 |
| PubChem | CID 3950 |
| DrugBank | DB01206 |
| ChemSpider | 3813 |
| UNII | 7BRF0Z81KG |
| KEGG | D00363 |
| ChEMBL | CHEMBL514 |
| Synonyms | 1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-urea |
| Chemical data | |
| Formula | C9H16ClN3O2 |
| Mol. mass | 233.695 g/mol |
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Lomustine (or "CCNU")(Marketed under the name CeeNU in US) is an alkylating nitrosourea compound used in chemotherapy. It is in the same family as streptozotocin. This is a highly lipid soluble drug, and thus crosses the blood brain barrier. This property makes it ideal for treating brain tumors, and is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).
Contents |
Dose [edit]
Adults: 100-150mg/m2 PO every 6 weeks (subsequent dose based on WBC) [1] Cats (7,5 kg): 15mg every 6 weeks Dogs: 60-90mg/m^2 every 3 weeks.
Dosage Form [edit]
10mg, 15mg, 40mg, 100mg Capsules
Other [edit]
It is the "C" in the "PCV" chemotherapy regimen.
References [edit]
- ^ Lexi-Comp Drug Information Handbook
External links [edit]
- Lomustine at the US National Library of Medicine Medical Subject Headings (MeSH)
- Patient information at cancerbackup.org.uk
- DDB 29525
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