Lomustine

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Lomustine
Systematic (IUPAC) name
N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a682207
Pregnancy cat.  ?
Legal status  ?
Routes Oral
Pharmacokinetic data
Protein binding 50%
Identifiers
CAS number 13010-47-4
ATC code L01AD02
PubChem CID 3950
DrugBank APRD00292
ChemSpider 3813 YesY
UNII 7BRF0Z81KG YesY
KEGG D00363 YesY
ChEMBL CHEMBL514 YesY
Synonyms 1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-urea
Chemical data
Formula C9H16ClN3O2 
Mol. mass 233.695 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Lomustine (or "CCNU")(Marketed under the name CeeNU in US) is an alkylating nitrosourea compound used in chemotherapy. It is in the same family as streptozotocin. This is a highly lipid soluble drug, and thus crosses the blood brain barrier. This property makes it ideal for treating brain tumors, and is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).


Contents

[edit] Dose

Adults: 100-150mg/m2 PO every 6 weeks (subsequent dose based on WBC) [1] Cats (7,5 kg): 15mg every 6 weeks

[edit] Dosage Form

10mg, 15mg, 40mg, 100mg Capsules

[edit] Other

It is the "C" in the "PCV" chemotherapy regimen.

[edit] References

  1. ^ Lexi-Comp Drug Information Handbook

[edit] External links



Personal tools
Namespaces
Variants
Actions
Navigation
Interaction
Toolbox
Print/export
Languages