Lomustine

Lomustine

Systematic (IUPAC) name
N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a682207
Pregnancy cat.	D
Legal status	?
Routes	Oral
Pharmacokinetic data
Protein binding	50%
Identifiers
CAS number	13010-47-4 Y
ATC code	L01AD02
PubChem	CID 3950
DrugBank	DB01206
ChemSpider	3813 Y
UNII	7BRF0Z81KG Y
KEGG	D00363 Y
ChEMBL	CHEMBL514 Y
Synonyms	1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-urea
Chemical data
Formula	C9H16ClN3O2
Mol. mass	233.695 g/mol
SMILES O=C(NC1CCCCC1)N(N=O)CCCl
InChI InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14) Y Key:GQYIWUVLTXOXAJ-UHFFFAOYSA-N Y
Y (what is this?)  (verify)

Lomustine (or "CCNU")(Marketed under the name CeeNU in US) is an alkylating nitrosourea compound used in chemotherapy. It is in the same family as streptozotocin. This is a highly lipid soluble drug, and thus crosses the blood brain barrier. This property makes it ideal for treating brain tumors, and is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).

Dose

Adults: 100-150mg/m² PO every 6 weeks (subsequent dose based on WBC) Cats (7,5 kg): 15mg every 6 weeks Dogs: 60-90mg/m^2 every 3 weeks.

Dosage Form

10mg, 15mg, 40mg, 100mg Capsules

Other

It is the "C" in the "PCV" chemotherapy regimen.

External links

• Lomustine at the US National Library of Medicine Medical Subject Headings (MeSH)
• Patient information at cancerbackup.org.uk
• DDB 29525