|Systematic (IUPAC) name|
|Legal status||Rx only|
|Mol. mass||233.695 g/mol|
| (what is this?)
Lomustine (or CCNU; marketed under the name CeeNU in U.S.) is an alkylating nitrosourea compound used in chemotherapy. It is in the same family as streptozotocin. This is a highly lipid soluble drug, and thus crosses the blood-brain barrier. This property makes it ideal for treating brain tumors, and is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).
- Adults: 100–150 mg/m2 PO every 6 weeks (subsequent dose based on WBC)
- Cats (7,5 kg): 15 mg every 6 weeks
- Dogs: 60–90 mg/m2 every 3 weeks
10 mg, 15 mg, 40 mg, 100 mg capsules
It is the "C" in the "PCV" chemotherapy regimen.
- Lexi-Comp Drug Information Handbook
- Lomustine at the US National Library of Medicine Medical Subject Headings (MeSH)
- Patient information at cancerbackup.org.uk
- DDB 29525
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