Masoprocol

Masoprocol

Systematic (IUPAC) name
4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	B (US)
Legal status	?
Routes	Topical
Pharmacokinetic data
Bioavailability	Very low
Identifiers
CAS number	500-38-9 Y
ATC code	L01XX10
PubChem	CID 71398
IUPHAR ligand	4265
DrugBank	DB00179
ChemSpider	64490 Y
UNII	7BO8G1BYQU Y
ChEMBL	CHEMBL313972 N
Chemical data
Formula	C18H22O4
Mol. mass	302.365 g/mol
SMILES Oc1ccc(cc1O)C[C@H](C)[C@H](C)Cc2ccc(O)c(O)c2
InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+ Y Key:HCZKYJDFEPMADG-TXEJJXNPSA-N Y
N (what is this?)  (verify)

Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer.

Also called nordihydroguaiaretic acid, NDGA, and actinex.

Mechanism

Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.

It is a lipoxygenase inhibitor.

External links

• MedlinePlus Drug Information
• Actinex entry in the public domain NCI Cancer Dictionary