Masoprocol

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Masoprocol
Masoprocol.svg
Systematic (IUPAC) name
4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
Clinical data
Trade names Actinex
AHFS/Drugs.com Micromedex Detailed Consumer Information
  • US: B (No risk in non-human studies)
Topical
Pharmacokinetic data
Bioavailability Very low
Identifiers
500-38-9 YesY
L01XX10
PubChem CID 71398
IUPHAR ligand 4265
DrugBank DB00179 YesY
ChemSpider 64490 YesY
UNII 7BO8G1BYQU YesY
ChEBI CHEBI:73468 N
ChEMBL CHEMBL313972 N
Chemical data
Formula C18H22O4
302.365 g/mol
 N (what is this?)  (verify)

Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer.

Also called nordihydroguaiaretic acid, NDGA, and actinex.

Mechanism[edit]

Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.

It is a lipoxygenase inhibitor.[1]

References[edit]

  1. ^ "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". Am. J. Physiol. Endocrinol. Metab. 279 (3): E593–600. September 2000. PMID 10950827. 

External links[edit]