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Cytochrome P450, family 39, subfamily A, polypeptide 1
Symbol CYP39A1
External IDs OMIM605994 MGI1927096 HomoloGene9580 IUPHAR: 1372 GeneCards: CYP39A1 Gene
EC number
Species Human Mouse
Entrez 51302 56050
Ensembl ENSG00000146233 ENSMUSG00000023963
UniProt Q9NYL5 Q9JKJ9
RefSeq (mRNA) NM_016593 NM_018887
RefSeq (protein) NP_057677 NP_061375
Location (UCSC) Chr 6:
46.52 – 46.62 Mb
Chr 17:
43.67 – 43.75 Mb
PubMed search [1] [2]

CYP39A1 (cytochrome P450, family 39, subfamily A, polypeptide 1) also known as oxysterol 7-α-hydroxylase 2 is a protein that in humans is encoded by the CYP39A1 gene.[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol.[2]


  1. ^ Li-Hawkins J, Lund EG, Bronson AD, Russell DW (June 2000). "Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol". J. Biol. Chem. 275 (22): 16543–9. doi:10.1074/jbc.M001810200. PMID 10748047. 
  2. ^ "Entrez Gene: CYP39A1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.