CYP39A1 (cytochrome P450, family 39, subfamily A, polypeptide 1) also known as oxysterol 7-α-hydroxylase 2 is a protein that in humans is encoded by the CYP39A1gene.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol.
Nelson DR, Zeldin DC, Hoffman SM et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.". Pharmacogenetics14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID15128046.CS1 maint: Explicit use of et al. (link)
Harrington JJ, Sherf B, Rundlett S et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol.19 (5): 440–5. doi:10.1038/88107. PMID11329013.CS1 maint: Explicit use of et al. (link)
Fourgeux C, Martine L, Björkhem I et al. (2009). "Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels.". Invest. Ophthalmol. Vis. Sci.50 (12): 5712–7. doi:10.1167/iovs.09-3655. PMID19553612.CS1 maint: Explicit use of et al. (link)