CYP3A43

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Cytochrome P450, family 3, subfamily A, polypeptide 43
Identifiers
Symbols CYP3A43 ; MGC119315; MGC119316
External IDs OMIM606534 MGI1930638 HomoloGene75118 ChEMBL: 5792 GeneCards: CYP3A43 Gene
EC number 1.14.14.1
RNA expression pattern
PBB GE CYP3A43 211440 x at tn.png
PBB GE CYP3A43 207773 x at tn.png
PBB GE CYP3A43 211441 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 64816 56388
Ensembl ENSG00000021461 ENSMUSG00000029630
UniProt Q9HB55 O09158
RefSeq (mRNA) NM_022820 NM_019792
RefSeq (protein) NP_073731 NP_062766
Location (UCSC) Chr 7:
99.43 – 99.46 Mb
Chr 5:
145.98 – 146.01 Mb
PubMed search [1] [2]

Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene.[1][2][3]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms.[3]

References[edit]

  1. ^ Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG (Feb 2001). "cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450". Mol Pharmacol 59 (2): 386–92. PMID 11160876. 
  2. ^ Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L (Mar 2001). "Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene". Pharmacogenetics 11 (2): 111–21. doi:10.1097/00008571-200103000-00002. PMID 11266076. 
  3. ^ a b "Entrez Gene: CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43". 

Further reading[edit]