25-Hydroxyvitamin D3 1-alpha-hydroxylase

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Cytochrome P450, family 27, subfamily B, polypeptide 1
Identifiers
Symbols CYP27B1 ; CP2B; CYP1; CYP1alpha; CYP27B; P450c1; PDDR; VDD1; VDDR; VDDRI; VDR
External IDs OMIM609506 MGI1098274 HomoloGene37139 ChEMBL: 5993 GeneCards: CYP27B1 Gene
EC number 1.14.13.13
Orthologs
Species Human Mouse
Entrez 1594 13115
Ensembl ENSG00000111012 ENSMUSG00000006724
UniProt O15528 O35084
RefSeq (mRNA) NM_000785 NM_010009
RefSeq (protein) NP_000776 NP_034139
Location (UCSC) Chr 12:
58.16 – 58.16 Mb
Chr 10:
127.05 – 127.05 Mb
PubMed search [1] [2]

25-Hydroxyvitamin D3 1-alpha-hydroxylase (VD3 1A hydroxylase) also known as cytochrome p450 27B1 (CYP27B1) is a cytochrome P450 enzyme that in humans is encoded by the CYP27B1 gene.[1][2][3]

VD3 1A hydroxylase is located in the proximal tubule of the kidney and a variety of other tissues, including skin (keratinocytes), immune cells,[4] and bone (osteoblasts).[5] The enzyme catalyzes the hydroxylation of Calcifediol to calcitriol (the bioactive form of Vitamin D):[6]

calcidiol + NADPH + H+ + O2 \rightleftharpoons calcitriol + NADP+ + H2O
calcidiol 1-monooxygenase
Identifiers
EC number 1.14.13.13
CAS number 9081-36-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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VitaminDSynthesis_WP1531 Go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article go to article go to article go to article Go to article go to article
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Vitamin D Synthesis Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531". 

References[edit]

  1. ^ "Entrez Gene: cytochrome P450". 
  2. ^ Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S (September 1997). "25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis". Science 277 (5333): 1827–30. doi:10.1126/science.277.5333.1827. PMID 9295274. 
  3. ^ Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T (October 1997). "Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase". Biochem. Biophys. Res. Commun. 239 (2): 527–33. doi:10.1006/bbrc.1997.7508. PMID 9344864. 
  4. ^ Sigmundsdottir H, Pan J, Debes GF, Alt C, Habtezion A, Soler D, Butcher EC (March 2007). "DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27". Nat. Immunol. 8 (3): 285–93. doi:10.1038/ni1433. PMID 17259988. 
  5. ^ Kogawa M, Findlay DM, Anderson PH, Ormsby R, Vincent C, Morris HA, Atkins GJ (October 2010). "Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption". Endocrinology 151 (10): 4613–25. doi:10.1210/en.2010-0334. PMID 20739402. 
  6. ^ Gray RW, Omdahl JL, Ghazarian JG, DeLuca HF (December 1972). "25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties". J. Biol. Chem. 247 (23): 7528–32. PMID 4404596. 

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