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Cytochrome P450, family 4, subfamily F, polypeptide 8
Symbols CYP4F8 ; CPF8; CYPIVF8
External IDs OMIM611545 MGI2146921 HomoloGene80199 IUPHAR: 1346 GeneCards: CYP4F8 Gene
EC number
RNA expression pattern
PBB GE CYP4F8 210576 at tn.png
More reference expression data
Species Human Mouse
Entrez 11283 106648
Ensembl ENSG00000186526 ENSMUSG00000073424
UniProt P98187 n/a
RefSeq (mRNA) NM_007253 NM_134127
RefSeq (protein) NP_009184 NP_598888
Location (UCSC) Chr 19:
15.73 – 15.74 Mb
Chr 17:
32.69 – 32.7 Mb
PubMed search [1] [2]

Cytochrome P450 4F8 is a protein that in humans is encoded by the CYP4F8 gene.[1][2]

This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away.[2]


  1. ^ Bylund J, Finnstrom N, Oliw EH (Aug 1999). "Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles". Biochem Biophys Res Commun 261 (1): 169–74. doi:10.1006/bbrc.1999.1011. PMID 10405341. 
  2. ^ a b "Entrez Gene: CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8". 

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