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Systematic (IUPAC) name
Clinical data
Legal status
  • Uncontrolled
Routes Oral
Pharmacokinetic data
Half-life 4-16 days
CAS number 126924-38-7
ATC code None
PubChem CID 4541
IUPHAR ligand 208
DrugBank DB06731
ChemSpider 4382
UNII 25CO3X0R31 YesY
Chemical data
Formula C16H16F3NO 
Molecular mass 295.30 g/mol

Seproxetine, also known as (S)-norfluoxetine, is a selective serotonin reuptake inhibitor (SSRI). It is the most important active metabolite of the widely used antidepressant fluoxetine, but little is known about its pharmacological actions. Seproxetine was being investigated by Eli Lilly and Company as an antidepressant; however, a cardiac side effect was noted and development was discontinued. The use of seproxetine was banned in Spain in 1998 after a study linked it to kidney damage.[citation needed]


Seproxetine can be synthesized from a protected 3-amino-1-phenylpropan-1-ol and 1-fluoro-4-trifluoromethyl(benzene):

Seproxetine synthesis: Fuller, R. W.; Robertson, D. W.; Wong, D. T.; European Patent, 1990, EP 0369685