Nitrosourea

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Nitrosourea
Skeletal formula of a minor tautomer of nitrosourea Ball and stick model a minor tautomer of nitrosourea
Identifiers
CAS number 13010-20-3 N
PubChem 105035
ChemSpider 94772 YesY
Jmol-3D images Image 1
Image 2
Properties
Molecular formula CH3N3O2
Molar mass 89.05 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Nitrosourea is both the name of a molecule, and a class of compounds that include a nitroso (R-NO) group and a urea.

Examples[edit]

Examples include:

Nitrosourea compounds are DNA alkylating agents and are often used in chemotherapy.[1] They are lipophilic and thus can cross the blood–brain barrier, making them useful in the treatment of brain tumors such as glioblastoma multiforme.[2]

Side effects[edit]

Some nitrosoureas (e.g. lomustine) have been associated with the development of interstitial lung disease.[3]

References[edit]

  1. ^ "Antineop". Retrieved 2009-01-24. 
  2. ^ Takimoto CH, Calvo E. "Principles of oncologic pharmacotherapy". in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds) Cancer management: a multidisciplinary approach. 11 ed. 2008.
  3. ^ Tucci E, Verdiani P, Di Carlo S, Sforza V (1986). "Lomustine (CCNU)-induced pulmonary fibrosis". Tumori 72 (1): 95–8. PMID 3952821. 

External links[edit]