Replication protein A1

Replication protein A1, 70kDa
	; PDB rendering based on 1ewi.
Available structures
PDB	1EWI, 1FGU, 1JMC, 1L1O, 2B29, 2B3G
Identifiers
Symbols	RPA1; HSSB; MST075; REPA1; RF-A; RP-A; RPA70
External IDs	OMIM: 179835 MGI: 1915525 HomoloGene: 2208 GeneCards: RPA1 Gene
Gene Ontology
Molecular function	• DNA binding; • single-stranded DNA binding; • protein binding; • metal ion binding;
Cellular component	• nucleus; • nucleoplasm; • nucleoplasm; • DNA replication factor A complex; • nucleolus; • cytoplasm; • actin cytoskeleton; • PML body;
Biological process	• cell cycle checkpoint; • G1/S transition of mitotic cell cycle; • S phase of mitotic cell cycle; • M/G1 transition of mitotic cell cycle; • mitotic cell cycle; • nucleotide-excision repair, DNA damage removal; • telomere maintenance via recombination; • telomere maintenance; • double-strand break repair via homologous recombination; • DNA recombinase assembly; • DNA replication; • DNA-dependent DNA replication; • DNA strand elongation involved in DNA replication; • DNA repair; • transcription-coupled nucleotide-excision repair; • nucleotide-excision repair; • nucleotide-excision repair, DNA gap filling; • double-strand break repair; • DNA recombination; • telomere maintenance via semi-conservative replication;
	Sources: Amigo / QuickGO
Orthologs

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Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene.^[1]

[edit] Interactions

Replication protein A1 has been shown to interact with RPA2,^[2]^[3] RPA3,^[3]^[4] MCM6,^[5] MCM7,^[5] MUTYH,^[6] BRCA2,^[7] ORC6L,^[5] ORC2L,^[5] TP53BP1,^[8] MCM4,^[5] P53,^[9]^[10] XPA,^[11] MCM2,^[5] TIPIN^[12] and Bloom syndrome protein.^[13]^[14]^[15]

[edit] References

^ Umbricht CB, Erdile LF, Jabs EW, Kelly TJ (Apr 1993). "Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A". J Biol Chem 268 (9): 6131–8. PMID 8454588.
^ Shao, R G; Cao C X, Zhang H, Kohn K W, Wold M S, Pommier Y (Mar. 1999). "Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes". EMBO J. (ENGLAND) 18 (5): 1397–406. doi:10.1093/emboj/18.5.1397. ISSN 0261-4189. PMC 1171229. PMID 10064605. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171229.
^ ^a ^b Bochkareva, Elena; Korolev Sergey, Lees-Miller Susan P, Bochkarev Alexey (Apr. 2002). "Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA". EMBO J. (England) 21 (7): 1855–63. doi:10.1093/emboj/21.7.1855. ISSN 0261-4189. PMC 125950. PMID 11927569. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125950.
^ Bochkareva, E; Frappier L, Edwards A M, Bochkarev A (Feb. 1998). "The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain". J. Biol. Chem. (UNITED STATES) 273 (7): 3932–6. doi:10.1074/jbc.273.7.3932. ISSN 0021-9258. PMID 9461578.
^ ^a ^b ^c ^d ^e ^f Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar. 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612.
^ Parker, A; Gu Y, Mahoney W, Lee S H, Singh K K, Lu A L (Feb. 2001). "Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair". J. Biol. Chem. (United States) 276 (8): 5547–55. doi:10.1074/jbc.M008463200. ISSN 0021-9258. PMID 11092888.
^ Wong, Johnson M S; Ionescu Daniela, Ingles C James (Jan. 2003). "Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2". Oncogene (England) 22 (1): 28–33. doi:10.1038/sj.onc.1206071. ISSN 0950-9232. PMID 12527904.
^ Yoo, Eunjae; Kim Byung U, Lee Seung Youn, Cho Chae Hyun, Chung Jay H, Lee Chang-Hun (Aug. 2005). "53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage". Oncogene (England) 24 (35): 5423–30. doi:10.1038/sj.onc.1208710. ISSN 0950-9232. PMID 15856006.
^ Romanova, Larisa Y; Willers Henning, Blagosklonny Mikhail V, Powell Simon N (Dec. 2004). "The interaction of p53 with replication protein A mediates suppression of homologous recombination". Oncogene (England) 23 (56): 9025–33. doi:10.1038/sj.onc.1207982. ISSN 0950-9232. PMID 15489903.
^ Riva, F; Zuco V, Vink A A, Supino R, Prosperi E (Dec. 2001). "UV-induced DNA incision and proliferating cell nuclear antigen recruitment to repair sites occur independently of p53-replication protein A interaction in p53 wild type and mutant ovarian carcinoma cells". Carcinogenesis (England) 22 (12): 1971–8. doi:10.1093/carcin/22.12.1971. ISSN 0143-3334. PMID 11751427.
^ Li, L; Lu X, Peterson C A, Legerski R J (Oct. 1995). "An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair". Mol. Cell. Biol. (UNITED STATES) 15 (10): 5396–402. ISSN 0270-7306. PMC 230789. PMID 7565690. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230789.
^ Unsal-Kaçmaz, Keziban; Chastain Paul D, Qu Ping-Ping, Minoo Parviz, Cordeiro-Stone Marila, Sancar Aziz, Kaufmann William K (Apr. 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Mol. Cell. Biol. (United States) 27 (8): 3131–42. doi:10.1128/MCB.02190-06. ISSN 0270-7306. PMC 1899931. PMID 17296725. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1899931.
^ Brosh, R M; Li J L, Kenny M K, Karow J K, Cooper M P, Kureekattil R P, Hickson I D, Bohr V A (Aug. 2000). "Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity". J. Biol. Chem. (UNITED STATES) 275 (31): 23500–8. doi:10.1074/jbc.M001557200. ISSN 0021-9258. PMID 10825162.
^ Opresko, Patricia L; von Kobbe Cayetano, Laine Jean-Philippe, Harrigan Jeanine, Hickson Ian D, Bohr Vilhelm A (Oct. 2002). "Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases". J. Biol. Chem. (United States) 277 (43): 41110–9. doi:10.1074/jbc.M205396200. ISSN 0021-9258. PMID 12181313.
^ Moens, Peter B; Kolas Nadine K, Tarsounas Madalena, Marcon Edyta, Cohen Paula E, Spyropoulos Barbara (Apr. 2002). "The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination". J. Cell. Sci. (England) 115 (Pt 8): 1611–22. ISSN 0021-9533. PMID 11950880.

[edit] Further reading

Iftode C, Daniely Y, Borowiec JA (1999). "Replication protein A (RPA): the eukaryotic SSB.". Crit. Rev. Biochem. Mol. Biol. 34 (3): 141–80. doi:10.1080/10409239991209255. PMID 10473346.
Binz SK, Sheehan AM, Wold MS (2005). "Replication protein A phosphorylation and the cellular response to DNA damage.". DNA Repair (Amst.) 3 (8-9): 1015–24. doi:10.1016/j.dnarep.2004.03.028. PMID 15279788.
Dornreiter I, Erdile LF, Gilbert IU, et al. (1992). "Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen.". EMBO J. 11 (2): 769–76. PMC 556510. PMID 1311258. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=556510.
Erdile LF, Heyer WD, Kolodner R, Kelly TJ (1991). "Characterization of a cDNA encoding the 70-kDa single-stranded DNA-binding subunit of human replication protein A and the role of the protein in DNA replication.". J. Biol. Chem. 266 (18): 12090–8. PMID 2050703.
Li L, Lu X, Peterson CA, Legerski RJ (1995). "An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair.". Mol. Cell. Biol. 15 (10): 5396–402. PMC 230789. PMID 7565690. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230789.
Keshav KF, Chen C, Dutta A (1995). "Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex.". Mol. Cell. Biol. 15 (6): 3119–28. PMC 230543. PMID 7760808. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230543.
Umbricht CB, Griffin CA, Hawkins AL, et al. (1994). "High-resolution genomic mapping of the three human replication protein A genes (RPA1, RPA2, and RPA3).". Genomics 20 (2): 249–57. doi:10.1006/geno.1994.1161. PMID 8020972.
Gomes XV, Wold MS (1996). "Functional domains of the 70-kilodalton subunit of human replication protein A.". Biochemistry 35 (32): 10558–68. doi:10.1021/bi9607517. PMID 8756712.
Bochkarev A, Pfuetzner RA, Edwards AM, Frappier L (1997). "Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA.". Nature 385 (6612): 176–81. doi:10.1038/385176a0. PMID 8990123.
Amacker M, Hottiger M, Mossi R, Hübscher U (1997). "HIV-1 nucleocapsid protein and replication protein A influence the strand displacement DNA synthesis of lentiviral reverse transcriptase.". AIDS 11 (4): 534–6. PMID 9084803.
Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.". Mol. Cell. Biol. 17 (4): 1817–23. PMC 232028. PMID 9121429. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232028.
Loor G, Zhang SJ, Zhang P, et al. (1998). "Identification of DNA replication and cell cycle proteins that interact with PCNA.". Nucleic Acids Res. 25 (24): 5041–6. doi:10.1093/nar/25.24.5041. PMC 147130. PMID 9396813. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=147130.
Bochkareva E, Frappier L, Edwards AM, Bochkarev A (1998). "The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain.". J. Biol. Chem. 273 (7): 3932–6. doi:10.1074/jbc.273.7.3932. PMID 9461578.
Golub EI, Gupta RC, Haaf T, et al. (1999). "Interaction of human rad51 recombination protein with single-stranded DNA binding protein, RPA.". Nucleic Acids Res. 26 (23): 5388–93. doi:10.1093/nar/26.23.5388. PMC 148005. PMID 9826763. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=148005.
Shao RG, Cao CX, Zhang H, et al. (1999). "Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes.". EMBO J. 18 (5): 1397–406. doi:10.1093/emboj/18.5.1397. PMC 1171229. PMID 10064605. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171229.
Brosh RM, Orren DK, Nehlin JO, et al. (1999). "Functional and physical interaction between WRN helicase and human replication protein A.". J. Biol. Chem. 274 (26): 18341–50. doi:10.1074/jbc.274.26.18341. PMID 10373438.
Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members.". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.
Brosh RM, Li JL, Kenny MK, et al. (2000). "Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity.". J. Biol. Chem. 275 (31): 23500–8. doi:10.1074/jbc.M001557200. PMID 10825162.

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[pmid8454588-0] Umbricht CB, Erdile LF, Jabs EW, Kelly TJ (Apr 1993). "Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A". J Biol Chem 268 (9): 6131–8. PMID 8454588.

[pmid10064605-1] Shao, R G; Cao C X, Zhang H, Kohn K W, Wold M S, Pommier Y (Mar. 1999). "Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes". EMBO J. (ENGLAND) 18 (5): 1397–406. doi:10.1093/emboj/18.5.1397. ISSN 0261-4189. PMC 1171229. PMID 10064605. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171229.

[pmid11927569-2] Bochkareva, Elena; Korolev Sergey, Lees-Miller Susan P, Bochkarev Alexey (Apr. 2002). "Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA". EMBO J. (England) 21 (7): 1855–63. doi:10.1093/emboj/21.7.1855. ISSN 0261-4189. PMC 125950. PMID 11927569. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125950.

[pmid9461578-3] Bochkareva, E; Frappier L, Edwards A M, Bochkarev A (Feb. 1998). "The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain". J. Biol. Chem. (UNITED STATES) 273 (7): 3932–6. doi:10.1074/jbc.273.7.3932. ISSN 0021-9258. PMID 9461578.

[pmid12614612-4] ^ ^a ^b ^c ^d ^e ^f Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar. 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612.

[pmid11092888-5] Parker, A; Gu Y, Mahoney W, Lee S H, Singh K K, Lu A L (Feb. 2001). "Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair". J. Biol. Chem. (United States) 276 (8): 5547–55. doi:10.1074/jbc.M008463200. ISSN 0021-9258. PMID 11092888.

[pmid12527904-6] Wong, Johnson M S; Ionescu Daniela, Ingles C James (Jan. 2003). "Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2". Oncogene (England) 22 (1): 28–33. doi:10.1038/sj.onc.1206071. ISSN 0950-9232. PMID 12527904.

[pmid15856006-7] Yoo, Eunjae; Kim Byung U, Lee Seung Youn, Cho Chae Hyun, Chung Jay H, Lee Chang-Hun (Aug. 2005). "53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage". Oncogene (England) 24 (35): 5423–30. doi:10.1038/sj.onc.1208710. ISSN 0950-9232. PMID 15856006.

[pmid15489903-8] Romanova, Larisa Y; Willers Henning, Blagosklonny Mikhail V, Powell Simon N (Dec. 2004). "The interaction of p53 with replication protein A mediates suppression of homologous recombination". Oncogene (England) 23 (56): 9025–33. doi:10.1038/sj.onc.1207982. ISSN 0950-9232. PMID 15489903.

[pmid11751427-9] Riva, F; Zuco V, Vink A A, Supino R, Prosperi E (Dec. 2001). "UV-induced DNA incision and proliferating cell nuclear antigen recruitment to repair sites occur independently of p53-replication protein A interaction in p53 wild type and mutant ovarian carcinoma cells". Carcinogenesis (England) 22 (12): 1971–8. doi:10.1093/carcin/22.12.1971. ISSN 0143-3334. PMID 11751427.

[pmid7565690-10] Li, L; Lu X, Peterson C A, Legerski R J (Oct. 1995). "An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair". Mol. Cell. Biol. (UNITED STATES) 15 (10): 5396–402. ISSN 0270-7306. PMC 230789. PMID 7565690. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230789.

[pmid17296725-11] Unsal-Kaçmaz, Keziban; Chastain Paul D, Qu Ping-Ping, Minoo Parviz, Cordeiro-Stone Marila, Sancar Aziz, Kaufmann William K (Apr. 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Mol. Cell. Biol. (United States) 27 (8): 3131–42. doi:10.1128/MCB.02190-06. ISSN 0270-7306. PMC 1899931. PMID 17296725. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1899931.

[pmid10825162-12] Brosh, R M; Li J L, Kenny M K, Karow J K, Cooper M P, Kureekattil R P, Hickson I D, Bohr V A (Aug. 2000). "Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity". J. Biol. Chem. (UNITED STATES) 275 (31): 23500–8. doi:10.1074/jbc.M001557200. ISSN 0021-9258. PMID 10825162.

[pmid12181313-13] Opresko, Patricia L; von Kobbe Cayetano, Laine Jean-Philippe, Harrigan Jeanine, Hickson Ian D, Bohr Vilhelm A (Oct. 2002). "Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases". J. Biol. Chem. (United States) 277 (43): 41110–9. doi:10.1074/jbc.M205396200. ISSN 0021-9258. PMID 12181313.

[pmid11950880-14] Moens, Peter B; Kolas Nadine K, Tarsounas Madalena, Marcon Edyta, Cohen Paula E, Spyropoulos Barbara (Apr. 2002). "The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination". J. Cell. Sci. (England) 115 (Pt 8): 1611–22. ISSN 0021-9533. PMID 11950880.

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Replication protein A1

[edit] Interactions

[edit] References

[edit] Further reading

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