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Revision as of 07:34, 16 July 2024

Chandipura vesiculovirus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Monjiviricetes
Order: Mononegavirales
Family: Rhabdoviridae
Genus: Vesiculovirus
Species:
Chandipura vesiculovirus
Synonyms[1]
  • Chandipura virus

Chandipura vesiculovirus (CHPV) is a member of the Rhabdoviridae family that is associated with an encephalitic illness in humans. It was first identified in 1965 after isolation from the blood of two patients from Chandipura village in Maharashtra state, India[2] and has been associated with a number of otherwise unexplained outbreaks of encephalitic illness in central India. The most recent occurred in Andhra Pradesh and Maharashtra in June–August 2003 with 329 children affected and 183 deaths.[3] Further sporadic cases and deaths in children were observed in Gujarat state in 2004.[4]

Chandipura vesiculovirus has been isolated from sandflies in India and West Africa [5] and is probably spread through its bite. The presence of the virus in Africa indicates a wide distribution although no human cases have been observed outside India.

The significance of Chandipura vesiculovirus as a human pathogen is unresolved due to doubts over its role in the 2003 and 2004 outbreaks.

Virology

Chandipura vesiculovirus is an enveloped RNA virus with an approximate genome length of ~11 kb. Viral genome codes for five polypeptides, namely, nucleocapsid protein N, phosphoprotein P, matrix protein M, glycoprotein G and large protein L in five monocistronic mRNAs. N protein encapsidates genome RNA into a nuclease-resistant form to protect in from cellular RNAse function. L and P protein together forms viral RNA dependent RNA polymerase; where catalytic functions for RNA polymerization, capping and poly-A polymerase resides within the L protein and P acts as a transcriptional activator. Matrix protein glues the encapsidated genome RNA, also known as nucleocapsid, with the outer membrane envelope. G protein spikes out of the membrane and acts as a major antigenic determinant.[6]

Viral life cycle is cytosolic. During transcription, viral polymerase synthesizes five discrete mRNAs and obeys to stop signals that are present at the gene boundaries. Accumulation of adequate amounts of viral proteins within infected cells through viral transcription and subsequent translation potentiate the onset of viral replicative cycle. In this phase, same L protein acts as a replicase and ignore the gene junctions to generate a polycistronic anti-genomic analogue that acts as a template for further rounds of replication to generate many more copies of the genome RNA. This progeny genome RNA upon packaging by viral proteins bud out as mature virus particles. The precise mechanism underlying the switch in polymerase function during viral replication remains unknown.[6]

Past outbreaks

In 2003, 329 children in Andhra Pradesh and Maharashtra were tested positive and 189 of them died.[7] In 2009, 52 people were tested positive and 15 of them died. In 2010, 50 people were tested positive of 16 of them died. Most of the infected patients were less than 14 years old. Between 2009 and 2011, 110 tested positive, and 3 died in 2011.[8]

An outbreak in Gujarat in Kheda District, Vadodara District, and Panchmahal District had killed 17 people in 2010.[9] Sandfly bites are blamed as they inhabit cracks in walls or parts of homes made of sand or mud. The sporadic cases appeared in Gujarat in 2014 and 2016. One girl died in Ahmedabad in 2016. In 2019 one girl died in Bhayli village of Vadodara.[10]

Recent outbreaks

In July 2024, Sabarkantha district of Gujarat in India experienced an outbreak particularly in children. This outbreak has raised significant public health concerns due to the rapid spread and the severity of symptoms observed in the affected individuals.[11][12]

References

  1. ^ Walker, Peter (15 June 2015). "Implementation of taxon-wide non-Latinized binomial species names in the family Rhabdoviridae" (PDF). International Committee on Taxonomy of Viruses (ICTV). p. 7. Retrieved 6 February 2019.
  2. ^ Bhatt, P. N.; Rodrigues, F. M. (December 1967). "Chandipura: A new Arbovirus Isolated in India from Patients with Febrile Illness". Indian Journal of Medical Research. 55 (12): 1295–1305. PMID 4970067.
  3. ^ Rao, B. L.; Basu, A.; Wairagkar, N. S.; Gore, M. M.; Arankalle, V. A.; Thakare, J. P.; Jadi, R. S.; Rao, K. A.; Mishra, A. C. (2004). "A Large Outbreak of Acute Encephalitis with High Fatality Rate in Children in Andhra Pradesh, India, in 2003, Associated with Chandipura Virus". Lancet. 364 (9437): 869–874. doi:10.1016/S0140-6736(04)16982-1. PMC 7137741. PMID 15351194.
  4. ^ Chadha, M. S.; Arankalle, V. A.; Jadi, R. S.; Joshi, M. V.; Thakare, J. P.; Mahadev, P. V.; Mishra, A. C. (September 2005). "An Outbreak of Chandipura Virus Encephalitis in the Eastern Districts of Gujarat State, India". American Journal of Tropical Medicine and Hygiene. 73 (3): 566–570. doi:10.4269/ajtmh.2005.73.566. PMID 16172482.
  5. ^ Fontenille, D.; Traore-Lamizana, M.; Trouillet, J.; Leclerc, A.; Mondo, M.; Ba, Y.; Digoutte, J. P.; Zeller H. G. (May 1994). "First Isolations of Arboviruses from Phlebotomine Sand Flies in West Africa". American Journal of Tropical Medicine and Hygiene. 50 (5): 570–574. doi:10.4269/ajtmh.1994.50.570. PMID 8203705.
  6. ^ a b Basak, S.; Mondal, A.; Polley, S.; Mukhopadhyay, S.; Chattopadhyay, D. (October 2007). "Reviewing Chandipura: A Vesiculovirus in Human Epidemics". Bioscience Reports. 27 (4–5): 275–298. doi:10.1007/s10540-007-9054-z. PMC 7087735. PMID 17610154.
  7. ^ "Four children die in Gujarat from suspected Chandipura virus infection". Gujarat Samachar. Retrieved 2024-07-14.
  8. ^ "Chandipura virus killed three, infected 11 in Maharashtra last year". The Times of India. 2012-06-11. ISSN 0971-8257. Retrieved 2024-07-14.
  9. ^ DNA Correspondent (2010-08-05). "Chandipura Virus Kills 17 in Gujarat". DNA—Daily News & Analysis. Gandhinagar. Retrieved 2012-02-24. {{cite news}}: |author= has generic name (help)
  10. ^ "5-year-old girl dies of Chandipura virus in Gujarat". Retrieved 26 July 2019.
  11. ^ "Chandipura Virus claims Six lives in Gujarat: Symptoms, precautions, treatments, how it spreads and all you need to know". The Economic Times. 2024-07-16. ISSN 0013-0389. Retrieved 2024-07-16.
  12. ^ "Chandipura virus outbreak reported in Gujarat. What we know". Hindustan Times. 2024-07-15. Retrieved 2024-07-16.
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