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ADAMTS10

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ADAMTS10
Identifiers
AliasesADAMTS10, ADAM-TS10, ADAMTS-10, WMS, WMS1, ADAM metallopeptidase with thrombospondin type 1 motif 10
External IDsOMIM: 608990; MGI: 2449112; HomoloGene: 81940; GeneCards: ADAMTS10; OMA:ADAMTS10 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282352
NM_030957

RefSeq (protein)

NP_001269281
NP_112219

Location (UCSC)Chr 19: 8.58 – 8.61 MbChr 17: 33.74 – 33.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 10 is an enzyme that in humans is encoded by the ADAMTS10 gene.[5]

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142303Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024299Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10".

Further reading