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Aliases ADAMTS3, ADAMTS-4, ADAM metallopeptidase with thrombospondin type 1 motif 3
External IDs MGI: 3045353 HomoloGene: 8596 GeneCards: ADAMTS3
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for ADAMTS3
Genomic location for ADAMTS3
Band 4q13.3 Start 72,280,969 bp[1]
End 72,569,386 bp[1]
RNA expression pattern
PBB GE ADAMTS3 214913 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 4: 72.28 – 72.57 Mb Chr 5: 89.68 – 89.88 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 3 is an enzyme that in humans is encoded by the ADAMTS3 gene.[5][6]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156140 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043635 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Tang BL, Hong W (Apr 1999). "ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats". FEBS Lett. 445 (2–3): 223–5. doi:10.1016/S0014-5793(99)00119-2. PMID 10094461. 
  6. ^ a b "Entrez Gene: ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3". 

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