ADAMTS3

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ADAMTS3
Identifiers
Aliases ADAMTS3, ADAMTS-4, ADAM metallopeptidase with thrombospondin type 1 motif 3
External IDs MGI: 3045353 HomoloGene: 8596 GeneCards: ADAMTS3
Genetically Related Diseases
dental caries[1]
RNA expression pattern
PBB GE ADAMTS3 214913 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014243

NM_001081401
NM_177872

RefSeq (protein)

NP_055058

n/a

Location (UCSC) Chr 4: 72.28 – 72.57 Mb Chr 5: 89.68 – 89.88 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 3 is an enzyme that in humans is encoded by the ADAMTS3 gene.[4][5]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues.[5]

References[edit]

  1. ^ "Diseases that are genetically associated with ADAMTS3 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Tang BL, Hong W (Apr 1999). "ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats". FEBS Lett. 445 (2–3): 223–5. doi:10.1016/S0014-5793(99)00119-2. PMID 10094461. 
  5. ^ a b "Entrez Gene: ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3". 

Further reading[edit]

External links[edit]