ADAM2

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ADAM2
Identifiers
Aliases ADAM2, CRYN1, CRYN2, CT15, FTNB, PH-30b, PH30, PH30-beta, ADAM metallopeptidase domain 2
External IDs MGI: 1340894 HomoloGene: 1127 GeneCards: ADAM2
RNA expression pattern
PBB GE ADAM2 207664 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278113
NM_001278114
NM_001464

NM_009618

RefSeq (protein)

NP_001265042
NP_001265043
NP_001455

NP_033748.2
NP_033748

Location (UCSC) Chr 8: 39.74 – 39.84 Mb Chr 14: 66.03 – 66.08 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 2 is an enzyme that in humans is encoded by the ADAM2 gene.[3][4][5]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF (August 1996). "Molecular cloning of the human fertilin beta subunit". Biochem Biophys Res Commun. 224 (2): 318–26. doi:10.1006/bbrc.1996.1027. PMID 8702389. 
  4. ^ Burkin HR, Burkin DJ, Davey PM, Griffin DK, Affara NA (June 1997). "Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB)". Genomics. 40 (1): 190–2. doi:10.1006/geno.1996.4531. PMID 9070941. 
  5. ^ a b "Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)". 

Further reading[edit]

External links[edit]