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Atrolysin E

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Atrolysin E
Identifiers
EC no.3.4.24.44
CAS no.172306-51-3
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Atrolysin E (EC 3.4.24.44, Crotalus atrox metalloendopeptidase e, hemorrhagic toxin e) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Cleavage of Asn3-Gln, Ser9-His and Ala14-Leu bonds in insulin B chain and Tyr14-Gln and Thr8-Ser in A chain. Cleaves type IV collagen at Ala73-Gln in alpha1(IV) and at Gly7-Leu in alpha2(IV)

This endopeptidase is present in the venom of the western diamondback rattlesnake (Crotalus atrox).

References

  1. ^ Bjarnason JB, Tu AT (August 1978). "Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e". Biochemistry. 17 (16): 3395–404. doi:10.1021/bi00609a033. PMID 210790.
  2. ^ Bjarnason JB, Fox JW (August 1983). "Proteolytic specificity and cobalt exchange of hemorrhagic toxin e, a zinc protease isolated from the venom of the western diamondback rattlesnake (Crotalus atrox)". Biochemistry. 22 (16): 3770–8. doi:10.1021/bi00285a009. PMID 6351911.
  3. ^ Baramova EN, Shannon JD, Bjarnason JB, Fox JW (May 1990). "Identification of the cleavage sites by a hemorrhagic metalloproteinase in type IV collagen". Matrix. 10 (2): 91–7. doi:10.1016/s0934-8832(11)80175-7. PMID 2374521.