Endothelin-converting enzyme 1
Appearance
Endothelin-converting enzyme 1 | |||||||||
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Identifiers | |||||||||
EC no. | 3.4.24.71 | ||||||||
CAS no. | 138238-81-0 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Endothelin-converting enzyme 1 (EC 3.4.24.71, endothelin-converting enzyme, ECE-1) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of the -Trp21-Val- bond in big endothelin to form endothelin 1
This metalloendopeptidase belongs to the peptidase family M13.
References
- ^ Takahashi M, Matsushita Y, Iijima Y, Tanzawa K (October 1993). "Purification and characterization of endothelin-converting enzyme from rat lung". The Journal of Biological Chemistry. 268 (28): 21394–8. PMID 8407980.
- ^ Shimada K, Takahashi M, Tanzawa K (July 1994). "Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells". The Journal of Biological Chemistry. 269 (28): 18275–8. PMID 8034569.
- ^ Xu D, Emoto N, Giaid A, Slaughter C, Kaw S, deWit D, Yanagisawa M (August 1994). "ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1". Cell. 78 (3): 473–85. doi:10.1016/0092-8674(94)90425-1. PMID 8062389.
External links
- Endothelin-converting+enzyme+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)