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Pyrrolobenzodiazepine

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Anthramycin contains pyrrolobenzodiazepine core
Not to be confused with pyrrolodiazepine.

Pyrrolobenzodiazepines (PBD) are a class of compound that may have antibiotic or anti-tumor properties.[1]

Some dimeric pyrrolobenzodiazepines are used as the cytotoxic drug payloads in antibody-drug conjugates, for example in SGN-CD33A.

References

  1. ^ Hartley JA (June 2011). "The development of pyrrolobenzodiazepines as antitumour agents". Expert Opinion on Investigational Drugs. 20 (6): 733–44. doi:10.1517/13543784.2011.573477. PMID 21457108.
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