|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||326.8 g·mol−1|
|3D model (JSmol)|
Alprazolam triazolobenzophenone is a chemical compound which can be both a synthetic precursor and a prodrug for the benzodiazepine derivative alprazolam. At neutral pH it readily cyclizes to alprazolam, while in acidic conditions alprazolam undergoes a ring-opening reaction back to the triazolobenzophenone. A series of related acyl derivatives was researched in the 1980s as injectable water-soluble prodrugs of alprazolam, but were never developed for medical use. Subsequently, this compound has been detected as a designer drug, first being identified from a seizure in Spain in March 2014.
- Cho MJ, Sethy VH, Haynes LC (August 1986). "Sequentially labile water-soluble prodrugs of alprazolam". Journal of Medicinal Chemistry. 29 (8): 1346–50. doi:10.1021/jm00158a004. PMID 3016261.
- "Novel Benzodiazepines. A review of the evidence of use and harms of Novel Benzodiazepines" (PDF). Advisory Council on the Misuse of Drugs. April 2020.