SH-053-R-CH3-2′F

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SH-053-R-CH3-2′F
SH-053-R-CH3-2′F.svg
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C23H18FN3O2
Molar mass 387.406 g/mol
3D model (Jmol)

SH-053-R-CH3-2′F is a drug used in scientific research which is a benzodiazepine derivative. It produces some of the same effects as other benzodiazepines, but is much more subtype-selective than most other drugs of this class, having high selectivity, binding affinity and efficacy at the α5 subtype of the GABAA receptor. This gives much tighter control of the effects produced, and so while SH-053-R-CH3-2′F retains sedative and anxiolytic effects, it does not cause ataxia at moderate doses.[1] SH-053-R-CH3-2′F also blocks the nootropic effects of the α5-selective inverse agonist PWZ-029, so amnesia is also a likely side effect.[2]

Replacement of the ester function by an amide, realized in the analog MP-III-022, improves selectivity, efficacy and kinetic behavior.[3]

See also[edit]

References[edit]

  1. ^ Savić MM, Huang S, Furtmüller R, Clayton T, Huck S, Obradović DI, Ugresić ND, Sieghart W, Bokonjić DR, Cook JM (Jan 2008). "Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists?". Neuropsychopharmacology. 33 (2): 332–9. doi:10.1038/sj.npp.1301403. PMID 17392731. 
  2. ^ Savić MM, Clayton T, Furtmüller R, Gavrilović I, Samardzić J, Savić S, Huck S, Sieghart W, Cook JM (May 2008). "PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats". Brain Research. 1208: 150–9. doi:10.1016/j.brainres.2008.02.020. PMC 2577822Freely accessible. PMID 18394590. 
  3. ^ Stamenić TT, Poe MM, Rehman S, Santrač A, Divović B, Scholze P, Ernst M, Cook JM, Savić MM (2016). "Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABAA receptors containing the α5 subunit". Eur. J. Pharmacol. 791: 433–443. doi:10.1016/j.ejphar.2016.09.016. PMC 5107132Freely accessible. PMID 27639297.