GYKI-52895

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GYKI-52895
GYKI 52895.svg
GYKI-52895-3d.png
Identifiers
Synonyms 4-(8,9-Dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)benzenamine
CAS Number
PubChem CID
ChemSpider
KEGG
Chemical and physical data
Formula C17H17N3O2
Molar mass 295.34 g/mol
3D model (Jmol)
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GYKI-52895 is a drug which is a 2,3-benzodiazepine derivative. Unlike other similar drugs, GYKI-52895 is a selective dopamine reuptake inhibitor,[1][2] which presumably would produce stimulant effects in vivo.[original research?] It's DRI activity is shared by numerous addictive drugs including amphetamine and it's derivatives (eg. dextromethamphetamine), cocaine, and methylphenidate and it's derivatives (eg. ethylphenidate). However, dopaminergic drugs are also prone to producing emetic effects such as in the case of apomorphine.

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References[edit]

  1. ^ Horváth K, Szabó H, Pátfalusi M, Berzsenyi P, Andrási F. Pharmacological Effects of GYKI 52895, a New Selective Dopamine Uptake Inhibitor. European Journal of Pharmacology. 1990; 183(4):1416-1417.
  2. ^ Huang CL, Chen HC, Huang NK, Yang DM, Kao LS, Chen JC, Lai HL, Chern Y. Modulation of Dopamine Transporter Activity by Nicotinic Acetylcholine Receptors and Membrane Depolarization in Rat Pheochromocytoma PC12 Cells. Journal of Neurochemistry. 1999; 72(6): 2437–2444.