Jump to content

FUT2

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by OAbot (talk | contribs) at 12:47, 16 April 2020 (Open access bot: doi added to citation with #oabot.). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

FUT2
Identifiers
AliasesFUT2, B12QTL1, SE, SEC2, Se2, sej, fucosyltransferase 2
External IDsOMIM: 182100; MGI: 109374; HomoloGene: 10325; GeneCards: FUT2; OMA:FUT2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001097638
NM_000511

NM_001271993
NM_018876

RefSeq (protein)

NP_000502
NP_001091107

NP_001258922
NP_061364

Location (UCSC)Chr 19: 48.7 – 48.71 MbChr 7: 45.3 – 45.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 gene.[5][6] It affects the secretor status of ABO antigens.[7]

Approximately 20% of Caucasians are non-secretors due to the G428A (rs601338) and C571T (rs492602?) nonsense mutations in FUT2 and therefore have strong although not absolute protection from the norovirus GII.4.[citation needed]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176920Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055978Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gerard G, Oriol R (Feb 1992). "The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9". Ann Hum Genet. 55 (Pt 3): 225–33. doi:10.1111/j.1469-1809.1991.tb00417.x. PMID 1763885.
  6. ^ "Entrez Gene: FUT2 fucosyltransferase 2 (secretor status included)".
  7. ^ "Names for H (ISBT 018) Blood Group Alleles" (PDF). www.isbtweb.org. Retrieved 2019-10-13.

Further reading