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RTI-353

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This is an old revision of this page, as edited by DMacks (talk | contribs) at 19:49, 23 June 2020 (Remove malformatted |molecular_weight= when infobox can autocalculate it, per Wikipedia talk:WikiProject Pharmacology#Molecular weights in drugboxes (via WP:JWB)). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

RTI-353
Identifiers
  • methyl (1R,2S,3S,5S)-3-(4-ethyl-3-iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H22INO2
Molar mass399.272 g·mol−1
3D model (JSmol)
  • CCC1=C(C=C(C=C1)[C@H]2C[C@@H]3CC[C@H]([C@H]2C(=O)OC)N3)I
  (verify)

RTI(-4229)-353 is a phenyltropane derived drug which acts as an SSRI.[1] Tamagnan et al. also made some phenyltropanes with high activity and selectivity for the SERT (pM affinity).[2]

References

  1. ^ Navarro HA, Xu H, Zhong D, Blough BE, Ross WP, Kuhar MJ, Carroll FI (September 2001). "[(125)I]3beta-(4-ethyl-3-iodophenyl)nortropane-2beta-carboxylic acid methyl ester ([(125)I]EINT): a potent and selective radioligand for the brain serotonin transporter". Synapse. 41 (3). New York, N.Y.: 241–7. doi:10.1002/syn.1081. PMID 11418937.
  2. ^ Tamagnan G, Alagille D, Fu X, Kula NS, Baldessarini RJ, Innis RB, Baldwin RM (January 2006). "Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[aryl or heteroaryl]phenyltropanes". Bioorganic & Medicinal Chemistry Letters. 16 (1): 217–20. doi:10.1016/j.bmcl.2005.09.016. PMID 16236497.



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