4-Fluoropethidine

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4-Fluoropethidine
4-Fluoromeperidine.png
Systematic (IUPAC) name
ethyl 4-(4-fluorophenyl)-1-methylpiperidine-4-carboxylate
Identifiers
ATC code none
PubChem CID 11184669
ChemSpider 9359754 YesY
ChEMBL CHEMBL112817 YesY
Synonyms 4-Fluoromeperidine, 4-Fluoropethidine
Chemical data
Formula C15H20FNO2
Molar mass 265.322 g/mol
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4-Fluoropethidine is a drug that is a derivative of pethidine (meperidine), which combines pethidine's opioid analgesic effects with increased monoamine reuptake inhibition. It is around 50% less potent than pethidine as an opioid analgesic, but conversely is 50% more potent as a dopamine reuptake inhibitor, with other derivatives such as the 4-iodo and 3,4-dichloro analogues being even more potent dopamine reuptake inhibitors again. However none of these compounds substitute for cocaine or produce stimulant effects in animals, suggesting that they still act primarily as opioid analgesic drugs in practice.[1] Its action and degree of relation to pethidine means that it may be controlled in those countries which have laws about controlled-substance analogues; it is not itself listed in the Controlled Substances Act 1970.[2]

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References[edit]

  1. ^ Lomenzo SA, Rhoden JB, Izenwasser S, Wade D, Kopajtic T, Katz JL, Trudell ML (March 2005). "Synthesis and biological evaluation of meperidine analogues at monoamine transporters". Journal of Medicinal Chemistry. 48 (5): 1336–43. doi:10.1021/jm0401614. PMID 15743177. 
  2. ^ http://www.deadiversion.usdoj.gov/fed_regs/quotas/2015/quotas/drugreg/index.html