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Centanafadine Legal status
(1R ,5S )-1-naphthalen-2-yl-3-azabicyclo[3.1.0]hexane
CAS Number PubChem CID ChemSpider UNII KEGG Formula C 15 H 15 N Molar mass 209.292 g·mol−1 3D model (JSmol )
C1=C(C=CC2=CC=CC=C12)[C@@]34C[C@@H]3CNC4
InChI=1S/C15H15N/c1-2-4-12-7-13(6-5-11(12)3-1)15-8-14(15)9-16-10-15/h1-7,14,16H,8-10H2/t14-,15+/m1/s1
Key:HKHCSWPSUSWGLI-CABCVRRESA-N
Centanafadine [1]
Site
IC50 (nM)
Action
Ref
SERT Tooltip Serotonin transporter
83 nM
Blocker
[1]
NET Tooltip Norepinephrine transporter
6 nM
Blocker
[1]
DAT Tooltip Dopamine transporter
38 nM
Blocker
[1]
Centanafadine (INN ) (former developmental code name EB-1020 ) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) that began its development with Euthymics Bioscience after they acquired DOV Pharmaceutical . It was developed as a treatment for attention-deficit hyperactivity disorder (ADHD) and inhibits the reuptake of norepinephrine , dopamine , and serotonin with a ratio of 1:6:14, respectively.[1] [2] [3] [4] In 2011, Euthymics Bioscience spun off its development of centanafadine to a new company called Neurovance.[5] [6] In March 2017, Otsuka Pharmaceutical acquired Neurovance and the rights to centanafadine.[7] As of January 2018, Otsuka's pipeline indicates it is in Phase III clinical trials.[8]
See also
References
External links
DAT Tooltip Dopamine transporter (DRIs Tooltip Dopamine reuptake inhibitors )
NET Tooltip Norepinephrine transporter (NRIs Tooltip Norepinephrine reuptake inhibitors )
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