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A-1,3-mannosyl-glycoprotein 4-b-N-acetylglucosaminyltransferase

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Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Identifiers
EC no.2.4.1.145
CAS no.86498-16-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
PRIAMprofile
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Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC 2.4.1.145, N-acetylglucosaminyltransferase IV, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV, beta-acetylglucosaminyltransferase IV, uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV, alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase, GnTIV) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase.[1] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor.

References

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  1. ^ Gleeson PA, Schachter H (May 1983). "Control of glycoprotein synthesis". The Journal of Biological Chemistry. 258 (10): 6162–73. PMID 6222042.
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