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Ceramide cholinephosphotransferase

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ceramide cholinephosphotransferase
Identifiers
EC no.2.7.8.3
CAS no.9026-14-6
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IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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In enzymology, a ceramide cholinephosphotransferase (EC 2.7.8.3) is an enzyme that catalyzes the chemical reaction

CDP-choline + N-acylsphingosine CMP + sphingomyelin

Thus, the two substrates of this enzyme are CDP-choline and N-acylsphingosine, whereas its two products are CMP and sphingomyelin.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-choline:N-acylsphingosine cholinephosphotransferase. This enzyme is also called phosphorylcholine-ceramide transferase. This enzyme participates in sphingolipid metabolism.

References

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  • Kennedy EP (1962). "[65d] Phosphorylcholine-glyceride transferase". Methods in Enzymology. Vol. 5. pp. 484–486. doi:10.1016/s0076-6879(62)05264-7. ISBN 978-0-12-181805-0.
  • Sribney M, Kennedy EP (December 1958). "The enzymatic synthesis of sphingomyelin". The Journal of Biological Chemistry. 233 (6): 1315–22. doi:10.1016/S0021-9258(18)49333-7. PMID 13610834.