Ethanolamine-phosphate cytidylyltransferase

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ethanolamine-phosphate cytidylyltransferase
EC no.
CAS no.9026-33-9
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, an ethanolamine-phosphate cytidylyltransferase (EC is an enzyme that catalyzes the chemical reaction

CTP + ethanolamine phosphate diphosphate + CDP-ethanolamine

Thus, the two substrates of this enzyme are CTP and ethanolamine phosphate, whereas its two products are diphosphate and CDP-ethanolamine.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:ethanolamine-phosphate cytidylyltransferase. Other names in common use include phosphorylethanolamine transferase, ET, CTP-phosphoethanolamine cytidylyltransferase, phosphoethanolamine cytidylyltransferase, and ethanolamine phosphate cytidylyltransferase. This enzyme participates in aminophosphonate metabolism and glycerophospholipid metabolism.


  • KENNEDY EP, WEISS SB (1956). "The function of cytidine coenzymes in the biosynthesis of phospholipides". J. Biol. Chem. 222 (1): 193–214. PMID 13366993.
  • Sundler R (1975). "Ethanolaminephosphate cytidylyltransferase. Purification and characterization of the enzyme from rat liver". J. Biol. Chem. 250 (22): 8585–90. PMID 241749.
  • Visedo-Gonzalez E, Dixon HB (1989). "2-Aminoethylarsonic acid as an analogue of ethanolamine phosphate Endowment of ethanolamine-phosphate cytidylyltransferase with CTP pyrophosphatase activity". Biochem. J. 260 (1): 299–301. PMC 1138663. PMID 2549956.