GDP-fucose protein O-fucosyltransferase 2
| protein O-fucosyltransferase 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | POFUT2 | ||||||
| Alt. symbols | C21orf80 | ||||||
| NCBI gene | 23275 | ||||||
| HGNC | 14683 | ||||||
| OMIM | 610249 | ||||||
| RefSeq | NM_133634 | ||||||
| UniProt | Q9Y2G5 | ||||||
| Other data | |||||||
| Locus | Chr. 21 q22.3 | ||||||
| |||||||
GDP-fucose protein O-fucosyltransferase 2 (POFUT2) is an enzyme responsible for adding fucose sugars in O linkage to serine or threonine residues in Thrombospondin repeats.[1] The protein is an inverting glycosyltransferase, which means that the enzyme uses GDP-β-L-fucose as a donor substrate and transfers the fucose in O linkage to the protein producing fucose-α-O-serine/threonine.
Almost all glycosyltransferases reside in the Golgi apparatus. However, POFUT2 as well as the related enzyme POFUT1 have recently been shown to reside in the endoplasmic reticulum.
References
External links
- POFUT2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)