Glucose-1-phosphate guanylyltransferase

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glucose-1-phosphate guanylyltransferase
Identifiers
EC number2.7.7.34
CAS number9033-13-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a glucose-1-phosphate guanylyltransferase (EC 2.7.7.34) is an enzyme that catalyzes the chemical reaction

GTP + alpha-D-glucose 1-phosphate diphosphate + GDP-glucose

Thus, the two substrates of this enzyme are GTP and alpha-D-glucose 1-phosphate, whereas its two products are diphosphate and GDP-glucose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:alpha-D-glucose-1-phosphate guanylyltransferase. Other names in common use include GDP glucose pyrophosphorylase, and guanosine diphosphoglucose pyrophosphorylase. This enzyme participates in starch and sucrose metabolism.

References[edit]

  • Danishefsky I, Heritier-Watkins O (1967). "Nucleoside diphosphate glucose pyrophosphorylases in mast cell tumors". Biochim. Biophys. Acta. 139 (2): 349–57. doi:10.1016/0005-2744(67)90038-1. PMID 6034677.