Glucose-1-phosphate thymidylyltransferase

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glucose-1-phosphate thymidylyltransferase
glucose-1-phosphate thymidylyltransferase tetramer, E.Coli
EC no.
CAS no.9026-03-3
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a glucose-1-phosphate thymidylyltransferase (EC is an enzyme that catalyzes the chemical reaction

dTTP + alpha-D-glucose 1-phosphate diphosphate + dTDP-glucose

Thus, the two substrates of this enzyme are dTTP and alpha-D-glucose 1-phosphate, whereas its two products are pyrophosphate and dTDP-glucose.[1]

This enzyme belongs to the family of transferases, to be specific, those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis.[2][3]


The systematic name of this enzyme class is dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase. Other names in common use include:

  • glucose 1-phosphate thymidylyltransferase,
  • dTDP-glucose synthase, dTDP-glucose pyrophosphorylase,
  • thymidine diphosphoglucose pyrophosphorylase,
  • thymidine diphosphate glucose pyrophosphorylase, and
  • TDP-glucose pyrophosphorylase.

Structural studies[edit]

As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes 1FXO, 1FZW, 1G0R, 1G1L, 1G23, 1G2V, 1G3L, 1H5R, 1H5S, 1H5T, 1IIM, 1IIN, 1LVW, 1MC3, 1MP3, 1MP4, 1MP5, 2GGO, and 2GGQ.


  1. ^ Samuel G, Reeves P (2003). "Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly". Carbohydr. Res. 338 (23): 2503–19. doi:10.1016/j.carres.2003.07.009. PMID 14670712.
  2. ^ Kornfeld S, Glaser L (June 1961). "The enzymic synthesis of thymidine-linked sugars. I. Thymidine diphosphate glucose". J. Biol. Chem. 236: 1791–4. PMID 13753209.
  3. ^ Pazur JH, Shuey EW (June 1961). "The enzymatic synthesis of thymidine diphosphate glucose and its conversion to thymidine diphosphate rhamnose". J. Biol. Chem. 236 (6): 1780–5. PMID 13733719.