Glycerate kinase

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glycerate kinase
Identifiers
EC number2.7.1.31
CAS number9026-61-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Glycerate kinase
Identifiers
SymbolGlyc_kinase
PfamPF02595
InterProIPR004381

In enzymology, a glycerate kinase (EC 2.7.1.31) is an enzyme that catalyzes the chemical reaction

ATP + (R)-glycerate ADP + 3-phospho-(R)-glycerate
or
ATP + (R)-glycerate ADP + 2-phospho-(R)-glycerate

Thus, the two substrates of this enzyme are ATP and (R)-glycerate, whereas its two products are ADP and either 3-phospho-(R)-glycerate or 2-phospho-(R)-glycerate.[1]

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:(R)-glycerate 3-phosphotransferase. Other names in common use include glycerate kinase (phosphorylating), D-glycerate 3-kinase, D-glycerate kinase, glycerate-3-kinase, GK, D-glyceric acid kinase, and ATP:D-glycerate 2-phosphotransferase. This enzyme participates in 3 metabolic pathways: serine/glycine/threonine metabolism, glycerolipid metabolism, and glyoxylate-dicarboxylate metabolism.

This enzyme had been thought to produce 3-phosphoglycerate, but some glycerate kinases produce 2-phosphoglycerate instead.[1]

Structural studies[edit]

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1TO6, 1X3L, and 2B8N.

References[edit]

  1. ^ a b Bartsch, Oliver; Hagemann, Martin; Bauwe, Hermann (2008-09-03). "Only plant-type (GLYK) glycerate kinases produce d-glycerate 3-phosphate". FEBS Letters. 582 (20): 3025–3028. doi:10.1016/j.febslet.2008.07.038. ISSN 0014-5793. PMID 18675808.
  • Doughty CC, Hayashi JA, Guenther HL (1966). "Purification and properties of D-glycerate 3-kinase from Escherichia coli". J. Biol. Chem. 241 (3): 568–72. PMID 5325263.
  • ICHIHARA A, GREENBERG DM (1957). "Studies on the purification and properties of D-glyceric acid kinase of liver". J. Biol. Chem. 225 (2): 949–58. PMID 13416296.