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Nicotinate riboside kinase

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Nicotinate riboside kinase
Identifiers
EC no.2.7.1.173
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

Nicotinate riboside kinase (EC 2.7.1.173, ribosylnicotinic acid kinase, nicotinic acid riboside kinase, NRK1) is an enzyme with systematic name ATP:beta-D-ribosylnicotinate 5-phosphotransferase.[1] This enzyme catalyses the following chemical reaction

ATP + beta-D-ribosylnicotinate ADP + nicotinate beta-D-ribonucleotide

The enzyme from yeast and human also acts as EC 2.7.1.22 (ribosylnicotinamide kinase).

References

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  1. ^ Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C (October 2007). "Nicotinamide riboside kinase structures reveal new pathways to NAD+". PLOS Biology. 5 (10): e263. doi:10.1371/journal.pbio.0050263. PMC 1994991. PMID 17914902.
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